Bats: Body mass index, forearm mass index, blood glucose levels and SLC2A2 genes for diabetes
文献类型：期刊论文
| 作者 | Meng FX1; Zhu L1,2; Huang WJ1; Irwin DM3; Zhang SY[*]1,4 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:X页码:e29960 |
| 通讯作者 | szhang@syau.edu.cn |
| 英文摘要 | Bats have an unusually large volume of endocrine tissue, with a large population of beta cells, and an elevated sensitivity to glucose and insulin. This makes them excellent animal models for studying diabetes mellitus. We evaluated bats as models for diabetes in terms of lifestyle and genetic factors. For lifestyle factors, we generated data sets of 149 body mass index (BMI) and 860 forearm mass index (FMI) measurements for different species of bats. Both showed negative inter-species correlations with blood glucose levels in sixteen bats examined. The negative inter-species correlations may reflect adaptation of a small insectivorous ancestor to a larger frugivore. We identified an 11 bp deletion in the proximal promoter of SLC2A2 that we predicted would disrupt binding sites for the transcription repressor ZNF354C. In frugivorous bats this could explain the relatively high expression of this gene, resulting in a better capacity to absorb glucose and decrease blood glucose levels. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by a grant from the National Natural Science Foundation of China (No. 31570382) to Shuyi Zhang. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10341]  |
| 专题 | 昆明动物研究所_其他 |
| 作者单位 | 1.State Key Laboratory of Estuarine and Coastal Research, East China Normal University, Shanghai 200062, China 2.Kunming Institute of Zoology, Chinese Academy of Sciences & University of Chinese Academy of Sciences, Kunming 650223, China 3.Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5S 2E8, Canada 4.Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China |
| 推荐引用方式 GB/T 7714 | Meng FX,Zhu L,Huang WJ,et al. Bats: Body mass index, forearm mass index, blood glucose levels and SLC2A2 genes for diabetes[J]. SCIENTIFIC REPORTS,2016,6(X):e29960. |
| APA | Meng FX,Zhu L,Huang WJ,Irwin DM,&Zhang SY[*].(2016).Bats: Body mass index, forearm mass index, blood glucose levels and SLC2A2 genes for diabetes.SCIENTIFIC REPORTS,6(X),e29960. |
| MLA | Meng FX,et al."Bats: Body mass index, forearm mass index, blood glucose levels and SLC2A2 genes for diabetes".SCIENTIFIC REPORTS 6.X(2016):e29960. |
入库方式： OAI收割
来源：昆明动物研究所
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