Analyzing the miRNA-Gene Networks to Mine the Important miRNAs under Skin of Human and Mouse
文献类型：期刊论文
| 作者 | Wu JH1,2,3,4,5; Gong Husile1,2; Bai YS[*]5,6; Zhang WG[*]1 |
| 刊名 | BIOMED RESEARCH INTERNATIONAL
 |
| 出版日期 | 2016 |
| 卷号 | 2016期号:X页码:e5469371 |
| 通讯作者 | Yongsheng.Bai@indstate.edu ; atcgnmbi@aliyun.com |
| 合作状况 | 其它 |
| 英文摘要 | Genetic networks provide new mechanistic insights into the diversity of species morphology. In this study, we have integrated the MGI, GEO, and miRNA database to analyze the genetic regulatory networks under morphology difference of integument of humans and mice. We found that the gene expression network in the skin is highly divergent between human and mouse. The GO term of secretion was highly enriched, and this category was specific in human compared to mouse. These secretion genes might be involved in eccrine system evolution in human. In addition, total 62,637 miRNA binding target sites were predicted in human integument genes (IGs), while 26,280 miRNA binding target sites were predicted in mouse IGs. The interactions between miRNAs and IGs in human aremore complex than those inmouse. Furthermore, hsa-miR-548, mmu-miR-466, andmmu-miR-467 have an enormous number of targets on IGs, which both have the role of inhibition of host immunity response. The pattern of distribution on the chromosome of these three miRNAs families is very different. The interaction of miRNA/IGs has added the new dimension in traditional gene regulation networks of skin. Our results are generating new insights into the gene networks basis of skin difference between human and mouse. |
| 收录类别 | 其他 |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (31560623 to Dr. Jianghong Wu and 31260538/31560622 to Dr. Wenguang Zhang), the Natu- ral Science Foundation of Inner Mongolian (2013MS0414), the Innovation Foundation of IMAAAHS (2013CXJJM09 to Dr. Jianghong Wu), State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences (GREKF13-02), and the China PostdoctoralScienceFoundation(2014M562351toJianghong Wu). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10570]  |
| 专题 | 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China 2.Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Hohhot 010031, China 3.Inner Mongolia Prataculture Research Center, Chinese Academy of Science, Hohhot 010031, China 4.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 5.Department of Biology, Indiana State University, Terre Haute, IN 47809, USA 6.The Center for Genomic Advocacy, Indiana State University, Terre Haute, IN 47809, USA |
| 推荐引用方式 GB/T 7714 | Wu JH,Gong Husile,Bai YS[*],et al. Analyzing the miRNA-Gene Networks to Mine the Important miRNAs under Skin of Human and Mouse[J]. BIOMED RESEARCH INTERNATIONAL,2016,2016(X):e5469371. |
| APA | Wu JH,Gong Husile,Bai YS[*],&Zhang WG[*].(2016).Analyzing the miRNA-Gene Networks to Mine the Important miRNAs under Skin of Human and Mouse.BIOMED RESEARCH INTERNATIONAL,2016(X),e5469371. |
| MLA | Wu JH,et al."Analyzing the miRNA-Gene Networks to Mine the Important miRNAs under Skin of Human and Mouse".BIOMED RESEARCH INTERNATIONAL 2016.X(2016):e5469371. |
入库方式： OAI收割
来源：昆明动物研究所
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