Hepatitis C virus complete genome sequences identified from China representing subtypes 6k and 6n and a novel, as yet unassigned subtype within genotype 6
文献类型：期刊论文
| 作者 | Lu L[*]1; Nakano T2; Kuiken C6; Robertson BH7; Hagedorn CH1; Li CH3,4; Fu YS5; Miller S1 |
| 刊名 | JOURNAL OF GENERAL VIROLOGY
 |
| 出版日期 | 2006 |
| 卷号 | 87期号:X页码:629–634 |
| 通讯作者 | llu@kumc.edu |
| 合作状况 | 其它 |
| 英文摘要 | Here, the complete genome sequences for three hepatitis C virus (HCV) variants identified from China and belonging to genotype 6 are reported: km41, km42 and gz52557. Their entire genome lengths were 9430, 9441 and 9448 nt, respectively; the 5' untranslated regions (UTRs) contained 341, 342 and 339 nt, followed by single open reading frames of 9045, 9045 and 9057 nt, respectively; the 3' UTRs, up to the poly(U) tracts, were 41, 51 and 52 nt, respectively. Phylogenetic analyses showed that km41 is classified into subtype 6k and km42 into subtype 6n. Although gz52557 clustered distantly with subtype 6g, it appeared to belong to a distinct subtype. Analysis with 53 and 105 partial core and NS5B region sequences, respectively, representing 17 subtypes from 6a to 6q and three unassigned isolates of genotype 6 in co-analyses demonstrated that gz52557 was equidistant from all of these isolates, indicating that it belongs to a novel subtype. However, based on a recent consensus that three or more examples are required for a new HCV subtype designation, it is suggested that gz52557 remains unassigned to any subtype. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by NIH grants CA-063064 and 5P20RR016443-04. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10582]  |
| 专题 | 昆明动物研究所_其他 |
| 作者单位 | 1.Division of Gastroenterology/Hepatology, Department of Medicine, University of Kansas Medical Center, 4035 Delp, MS 1023, Kansas City, KS 66160, USA 2.Department of Internal Medicine, Ichinomiya Nishi Hospital, Ichinomiya, Aichi, Japan 3.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 4.Graduate School of the Chinese Academy of Sciences, Beijing, China 5.Guangzhou Blood Center, Guangzhou City, Guangdong Province, China 6.Los Alamos National Laboratory, Los Alamos, NM, USA 7.National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA |
| 推荐引用方式 GB/T 7714 | Lu L[*],Nakano T,Kuiken C,et al. Hepatitis C virus complete genome sequences identified from China representing subtypes 6k and 6n and a novel, as yet unassigned subtype within genotype 6[J]. JOURNAL OF GENERAL VIROLOGY,2006,87(X):629–634. |
| APA | Lu L[*].,Nakano T.,Kuiken C.,Robertson BH.,Hagedorn CH.,...&Miller S.(2006).Hepatitis C virus complete genome sequences identified from China representing subtypes 6k and 6n and a novel, as yet unassigned subtype within genotype 6.JOURNAL OF GENERAL VIROLOGY,87(X),629–634. |
| MLA | Lu L[*],et al."Hepatitis C virus complete genome sequences identified from China representing subtypes 6k and 6n and a novel, as yet unassigned subtype within genotype 6".JOURNAL OF GENERAL VIROLOGY 87.X(2006):629–634. |
入库方式： OAI收割
来源：昆明动物研究所
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