Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis
文献类型：期刊论文
| 作者 | Lu L[*]1; Li CH1,2; Hagedorn CH1 |
| 刊名 | REVIEWS IN MEDICAL VIROLOGY
 |
| 出版日期 | 2006 |
| 卷号 | 16期号:1页码:5-36 |
| 通讯作者 | llu@kumc.edu |
| 合作状况 | 其它 |
| 英文摘要 | Nucleotide sequences from a total of 421 HEV isolates were retrieved from Genbank and analysed. Phylogenetically, HEV was classified into four major genotypes. Genotype I was more conserved and classified into five subtypes. The number of genotype 2 sequences was limited but can be classified into two subtypes. Genotypes 3 and 4 were extremely diverse and can be subdivided into ten and seven subtypes. Geographically, genotype I was isolated from tropical and several subtropical countries in Asia and Africa, and genotype 2 was from Mexico, Nigeria, and Chad; whereas genotype 3 was identified almost worldwide including Asia, Europe, Oceania, North and South America. In contrast, genotype 4 was found exclusively in Asia. It is speculated that genotype 3 originated in the western hemisphere and was imported to several Asian countries such as Japan, Korea and Taiwan, while genotype 4 has been indigenous and likely restricted to Asia. Genotypes 3 and 4 were not only identified in swine but also in wild animals such as boar and a deer. Furthermore, in most areas where genotypes 3 and 4 were characterised, sequences from both humans and animals were highly conserved, indicating they originated from the same infectious sources. Based upon nucleotide differences from five phylogenies, it is proposed that five, two, ten and seven subtypes for HEV genotypes 1, 2, 3 and 4 be designated alphabetised subtypes. Accordingly, a total of 24 subtypes (1a, 1b, 1c, Id, le, 2a, 2b, 3a, 3b, 3c, 3d, 3e, 3f, 3g, 3h, 3i, 3j, 4a, 4b, 4c, 4d, 4e, 4f and 4g) were given. |
| 收录类别 | SCI |
| 资助信息 | Supported by NIH grant 5 P20 RR016443-04. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10590]  |
| 专题 | 昆明动物研究所_其他 |
| 作者单位 | 1.Division of Gastroenterology/Hepatology, Department of Medicine, Kansas University Medical Center, Kansas City, Kansas, USA 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming City, China |
| 推荐引用方式 GB/T 7714 | Lu L[*],Li CH,Hagedorn CH. Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis[J]. REVIEWS IN MEDICAL VIROLOGY,2006,16(1):5-36. |
| APA | Lu L[*],Li CH,&Hagedorn CH.(2006).Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis.REVIEWS IN MEDICAL VIROLOGY,16(1),5-36. |
| MLA | Lu L[*],et al."Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis".REVIEWS IN MEDICAL VIROLOGY 16.1(2006):5-36. |
入库方式： OAI收割
来源：昆明动物研究所
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