Integrative transcriptomic analysis of NAFLD animal model reveals dysregulated genes and pathways in metabolism
文献类型：期刊论文
| 作者 | Yang WH1; He Y1; Wang J3; Liang J1; Dong Y1; Wang Q1; Hou ZL[*]1; Yang L[*]2; Liu SJ1; Gan L1 |
| 刊名 | GENE
 |
| 出版日期 | 2016 |
| 卷号 | 595期号:1页码:99-108 |
| 关键词 | Non-alcoholic fatty liver disease Animal model RNA sequencing Bioinformatic analysis Metabolism |
| 通讯作者 | hzl579@163.com |
| 合作状况 | 其它 |
| 英文摘要 | Dysregulation of metabolism in hepatocytes leads to hepatic diseases such as hepatitis and non-alcoholic fatty liver disease (NAFLD). NAFLD represents a spectrum of liver diseases ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). NASH is likely to progress to cirrhosis, liver failure and hepatocellular carcinoma, which lead to poor long-term prognosis. However, the exact mechanism of development of NAFLD is not well elucidated. In order to better understand the pathogenesis of NAFLD, we have performed an integrative analysis to livers from NAFLD rat models in a global view of the transcriptome. By systemic and integrative analyses, we have found that transport, angiogenesis and cell adhesion were upregulated in response to high fat diet feeding, which may cause a large amount of free fatty acid transport, hepatic fibrosis and hepatocytes injury. GO tree analysis has shown that angiogenesis was upregulated. GO term in response to high fat diet which may cause fibrosis. The pathway interaction network has indicated that upregulated "valine, leucine, and isoleucine metabolism" may decrease the serum concentration of branched-chain amino acid (BCAA). The enhanced degradation of BCAA in NAFLD animal models may lead to inhibition of the regeneration of hepatocytes, reducing the production of albumin, attenuating the inhibition of liver cancer and decreasing immunity. Overall, high fat diet upregulated a variety of metabolism which have converged at TCA cycle. High fatty has pushed the hepatic mitochondria to a "busy state". Comprehensively, genes participated in dysregulated biological process and metabolisms may be served as indicators for evaluation of NAFLD progression and therapeutic targets. |
| 资助信息 | This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10754]  |
| 专题 | 昆明动物研究所_其他 |
| 作者单位 | 1.Department of Geriatrics, Yan'an Affiliated Hospital of Kunming Medical University, Kunming 650051, Yunnan, People's Republic of China 2.Department of Central Laboratory, Yan'an Affiliated Hospital of Kunming Medical University, Kunming 650051, Yunnan, People's Republic of China 3.Kunming Institute of Zoology, Chinese Academy of Science, Kunming 650223, People's Republic of China |
| 推荐引用方式 GB/T 7714 | Yang WH,He Y,Wang J,et al. Integrative transcriptomic analysis of NAFLD animal model reveals dysregulated genes and pathways in metabolism[J]. GENE,2016,595(1):99-108. |
| APA | Yang WH.,He Y.,Wang J.,Liang J.,Dong Y.,...&Zhang ZG.(2016).Integrative transcriptomic analysis of NAFLD animal model reveals dysregulated genes and pathways in metabolism.GENE,595(1),99-108. |
| MLA | Yang WH,et al."Integrative transcriptomic analysis of NAFLD animal model reveals dysregulated genes and pathways in metabolism".GENE 595.1(2016):99-108. |
入库方式： OAI收割
来源：昆明动物研究所
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