猫基底前脑胆碱能皮质投射神经元区的P物质样免疫反应神经元
文献类型：期刊论文
| 作者 | 黄耀德1; 洪秀华2; 何宇红3; 康朝胜3; 蔡景霞4; 王建红4 |
| 刊名 | 动物学研究
 |
| 出版日期 | 1999 |
| 卷号 | 20期号:1页码:26-31 |
| 关键词 | P物质 胆碱乙酰化酶 隔区 斜角带核 Meynert基底核 |
| ISSN号 | 0254-5853 |
| 中文摘要 | 应用免疫组织化学和邻位切片法，研究了猫基底前脑胆碱能皮质投射神经元区的Ｐ物质样免疫反应神经元的分布特征，及其与胆碱乙酰化酶样免疫反应神经元的分布关系。从内侧隔核至Ｍｅｙｎｅｒｔ基底核，２种神经元分布范围相近，且形态、大小相似。但在邻位切片，未见分别呈此二免疫反应的同一神经元的对应剖面。Ｐ物质样免疫反应神经元在内侧隔核和斜角带核数量较多，但在基底核明显减少，在Ｃｈ４间质部及腹侧苍白球连合下部仅为偶见。结果表明，在内侧隔核－斜角带核－基底核，Ｐ物质能神经元主要分布在内侧隔核－斜角带核，多数Ｐ物质能和胆碱能神经元各自归属不同的神经元亚群。以上提示，在隔－海马投射系中，除胆碱能和ＧＡＢＡ能神经元，Ｐ物质能神经元是又一重要成分，可能对新皮质－海马－新皮质记忆环路有重要影响。 |
| 英文摘要 | The distribution of the substance P-like immunoreactive (SP-LI) neurons in the basal forebrain cholinergic corticopetal neuron areas in the cat was studied and compared with that of the choline acetyltransferase-like immunoreactive (ChAT-LI) neurons in the paired consecutive sections of the corresponding areas.A continuum of ChAT-LI neurons were distributed in the medial septal nucleus (MS),nuclei of diagonal band,vertical and horizontal divisions (NDBV/H),nucleus basalis of Meynert (NBM),subcommissural ventral pallidum (sVP),and the areas of interstitial elements of Ch4,e.g.the internal capsule (ic) and nucleus of anterior commissure (Nac).The distribution of the SP-LI neurons closely resembled that of the ChAT-LI neurons with similar shape and size in the corresponding areas of the MS-NDB-NBM continuum.However,no perikarya in the paired surfaces of two adjacent sections could be really identified as bisected neurons being SP- and ChAT-LI respectively.The number of the SP-LI neurons,compared with that of the ChAT-LI neurons was more in MS,almost the same in NDBV/H,much less in NBM,and only a few in the interstitial elements of Ch4 areas and sVP.The results demonstrated that the majority of the SP-LI neurons in the MSNDB-NBM were mainly contained in the MS-NDB and most of the SP-LI neurons in the cholinergic neuron areas belonged to a subdivision with different chemical property.We suggested that the Spergic neurons in the MS-NDB might be one of the main components,in addition to the cholinergic and GABAergic neurons,in the septohippocampal projection system and might play an important role in modulation of the memory-functioning neocortex-hippocampusneocortex circuit. |
| 收录类别 | 其他 |
| 原文出处 | 199920126.pdf |
| 语种 | 中文 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/3679]  |
| 专题 | 昆明动物研究所_其他 昆明动物研究所_神经系统编码 |
| 作者单位 | 1.上海第二医科大学基础医学院解剖教研室 2.瑞金临床医学院;200025 3.贵阳医学院解剖教研室;550004 4.中国科学院昆明动物研究所灵长类生物学研究室,昆明650223 |
| 推荐引用方式 GB/T 7714 | 黄耀德,洪秀华,何宇红,等. 猫基底前脑胆碱能皮质投射神经元区的P物质样免疫反应神经元[J]. 动物学研究,1999,20(1):26-31. |
| APA | 黄耀德,洪秀华,何宇红,康朝胜,蔡景霞,&王建红.(1999).猫基底前脑胆碱能皮质投射神经元区的P物质样免疫反应神经元.动物学研究,20(1),26-31. |
| MLA | 黄耀德,et al."猫基底前脑胆碱能皮质投射神经元区的P物质样免疫反应神经元".动物学研究 20.1(1999):26-31. |
入库方式： OAI收割
来源：昆明动物研究所
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