GABA and its agonists improved visual cortical function in senescent monkeys
文献类型：期刊论文
| 作者 | Leventhal AG[*]1; Wang YC1; Pu ML1; Zhou YF2; Ma YY3 |
| 刊名 | SCIENCE
 |
| 出版日期 | 2003 |
| 卷号 | 300期号:5620页码:812-815 |
| ISSN号 | 0036-8075 |
| 通讯作者 | audie.leventhal@m.cc.utah.edu |
| 合作状况 | 其它 |
| 英文摘要 | Human cerebral cortical function degrades during old age. Much of this change may result from a degradation of intracortical inhibition during senescence. We used multibarreled microelectrodes to study the effects of electrophoretic application of gamma-aminobutyric acid (GABA), the GABA type a (GABAa) receptor agonist muscimol, and the GABAa receptor antagonist bicuculline, respectively, on the properties of individual V1 cells in old monkeys. Bicuculline exerted a much weaker effect on neuronal responses in old than in young animals, confirming a degradation of GABA-mediated inhibition. On the other hand, the administration of GABA and muscimol resulted in improved visual function. Many treated cells in area V1 of old animals displayed responses typical of young cells. The present results have important implications for the treatment of the sensory, motor, and cognitive declines that accompany old age. |
| 收录类别 | SCI |
| 原文出处 | 2003300812.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5423]  |
| 专题 | 昆明动物研究所_认知障碍病理学 |
| 作者单位 | 1.Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA 2.School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, China 3.Lab- oratory of Primate Cognitive Neuroscience, Kunming Institute of Zoology, Chinese Academy of Science, Kun- ming, Yunnan 650223, China |
| 推荐引用方式 GB/T 7714 | Leventhal AG[*],Wang YC,Pu ML,et al. GABA and its agonists improved visual cortical function in senescent monkeys[J]. SCIENCE,2003,300(5620):812-815. |
| APA | Leventhal AG[*],Wang YC,Pu ML,Zhou YF,&Ma YY.(2003).GABA and its agonists improved visual cortical function in senescent monkeys.SCIENCE,300(5620),812-815. |
| MLA | Leventhal AG[*],et al."GABA and its agonists improved visual cortical function in senescent monkeys".SCIENCE 300.5620(2003):812-815. |
入库方式： OAI收割
来源：昆明动物研究所
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