Differently lasting effects of prenatal and postnatal chronic clozapine/haloperidol on activity and memory in mouse offspring
文献类型：期刊论文
| 作者 | Wang JH1,2; Yang JZ1; Wilson FAW1; Ma YY[*]1 |
| 刊名 | PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
 |
| 出版日期 | 2006 |
| 卷号 | 84期号:3页码:468-478 |
| 关键词 | Haloperidol Clozapine Offspring Open-field Step-through Water-maze |
| ISSN号 | 0091-3057 |
| 通讯作者 | yuanma0716@vip.sina.com |
| 合作状况 | 其它 |
| 英文摘要 | We evaluated the behavioral effects of chronic haloperidol (HAL) and clozapine (CLO) during gestation and CNS development, compared with transient treatments that stopped 1-3 weeks before the test. RESULTS: 1) Chronic HAL (6 mg/l in drinking water) but not HAL-withdrawal caused hypo-activity in open-field test on postnatal days (PNDs) 35, 42 and 56. However, hyper-activity was found in both CLO (90 mg/l) and CLO-withdrawal pups. 2) In the step-through test, retention performance was significantly higher in HAL-treated mice than in the controls on PND 42, as well as in withdrawal mice on PNDs 35 and 42. However, both chronic CLO (90 mg/l) exposure and CLO-withdrawal tended to improve the acquisition of memory. Furthermore, chronic CLO (180 mg/l) ameliorated scopolamine (3 mg/kg)-induced impairment of memory on PND 56. 3) In the water-maze test, both chronic HAL and HAL-withdrawal treatments significantly impaired performance on the 4th training day at PND 35, but not PNDs 42 and 56. Neither chronic CLO exposure nor CLO-withdrawal affected spatial memory. 4) Body weight following HAL/CLO administration decreased when compared with the controls during PND 21-35, but approached control levels at PND 40. CONCLUSION: HAL doesn't elicit permanent behavioral changes in offspring. By contrast, CLO had longer-lasting effects than HAL. The pups at age before PND 35 seem more sensitive to HAL/CLO than elder pups. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the National Science Foundation of China (NSFC 30470553 and 30530270) and the Program of Chinese Academy of Science. |
| 原文出处 | 200684468.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5445]  |
| 专题 | 昆明动物研究所_认知障碍病理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_神经系统编码 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms and Section of Cognitive Brain Research, Kunming Institute of Zoology, Chinese Academy of Sciences, #32 Jiao Chang Dong Lu, Kunming, Yunnan, 650223, PR China 2.Graduate School of Chinese Academy of Sciences, Beijing, PR China |
| 推荐引用方式 GB/T 7714 | Wang JH,Yang JZ,Wilson FAW,et al. Differently lasting effects of prenatal and postnatal chronic clozapine/haloperidol on activity and memory in mouse offspring[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2006,84(3):468-478. |
| APA | Wang JH,Yang JZ,Wilson FAW,&Ma YY[*].(2006).Differently lasting effects of prenatal and postnatal chronic clozapine/haloperidol on activity and memory in mouse offspring.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,84(3),468-478. |
| MLA | Wang JH,et al."Differently lasting effects of prenatal and postnatal chronic clozapine/haloperidol on activity and memory in mouse offspring".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 84.3(2006):468-478. |
入库方式： OAI收割
来源：昆明动物研究所
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