Improved spatial recognition memory in mice lacking adenosine A(2A) receptors
文献类型：期刊论文
| 作者 | Wang JH1,2,3; Ma YY[*]1; Van den Buuse M[*]3 |
| 刊名 | EXPERIMENTAL NEUROLOGY
 |
| 出版日期 | 2006 |
| 卷号 | 199期号:2页码:438-445 |
| 关键词 | Adenosine Knockout Wild type Y-maze |
| ISSN号 | 0014-4886 |
| 通讯作者 | yuanma0716@vip.sina.com ; mvandenbuuse@mhri.edu.au |
| 英文摘要 | Adenosine receptors play an important role in learning and memory as their antagonists have been found to facilitate learning and memory in various tasks in rodents. However, few studies have examined the effect of adenosine A2A receptor deficiency on cognition. In the present study, we therefore used the Y-maze, a simple two-trial recognition test to measure spatial recognition memory in mice lacking adenosine A2A receptors. The results showed that adenosine A2A receptor knockout mice had a higher percentage of novel arm visits as first choice than wild-type CD1 mice. Moreover, these mice showed longer duration of visits in the novel arm when compared with controls, suggesting that the lack of adenosine A2A receptors improved spatial recognition memory. On the other hand, mice lacking the adenosine A2A receptors had low scores in the number of arm visits, suggesting that they were hypoactive. In conclusion, these data suggest the involvement of adenosine receptors in modulating spatial recognition memory in mice, consistent with earlier findings using adenosine receptor antagonists. |
| 收录类别 | SCI |
| 资助信息 | National Science Foundation of China (NSFC 30470553 and 30530270). |
| 原文出处 | 2006199438.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5447]  |
| 专题 | 昆明动物研究所_认知障碍病理学 昆明动物研究所_神经系统编码 |
| 作者单位 | 1.Section of Cognitive Brain Research, Kunming Institute of Zoology, Chinese Academy of Sciences, #32 Jiao Chang Dong Lu Kunming, Yunnan #650223, PR China 2.Graduate School of Chinese Academy of Sciences, Beijing, PR China 3.Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Victoria #3052, Australia |
| 推荐引用方式 GB/T 7714 | Wang JH,Ma YY[*],Van den Buuse M[*]. Improved spatial recognition memory in mice lacking adenosine A(2A) receptors[J]. EXPERIMENTAL NEUROLOGY,2006,199(2):438-445. |
| APA | Wang JH,Ma YY[*],&Van den Buuse M[*].(2006).Improved spatial recognition memory in mice lacking adenosine A(2A) receptors.EXPERIMENTAL NEUROLOGY,199(2),438-445. |
| MLA | Wang JH,et al."Improved spatial recognition memory in mice lacking adenosine A(2A) receptors".EXPERIMENTAL NEUROLOGY 199.2(2006):438-445. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。