Ketamine affects memory consolidation: Differential effects in T-maze and passive avoidance paradigms in mice
文献类型：期刊论文
| 作者 | Wang JH1,2; Fu Y1,2; Wilson FAW[*]1; Ma YY[*]1 |
| 刊名 | NEUROSCIENCE
 |
| 出版日期 | 2006 |
| 卷号 | 140期号:3页码:993-1002 |
| 关键词 | memory consolidation retrieval step-through T-maze ketamine |
| ISSN号 | 0306-4522 |
| 通讯作者 | fraser@email.arizona.edu ; yuanma0716@vip.sina.com |
| 合作状况 | 其它 |
| 英文摘要 | The effects of ketamine, an N-methyl-D-aspartate (NMDA) antagonist, on memory in animals have been limited to the sub-anesthetic dose given prior to training in previous studies. We evaluated the effects of post-training anesthetic doses of ketamine to selectively manipulate memory consolidation, and the effect of pre-retention sub-anesthetic doses of ketamine on memory retrieval in passive avoidance and T-maze tasks in mice. Repeated post-training anesthetic doses of ketamine impaired the consolidation of memory in the T-maze but not in passive avoidance paradigms. This impairment was not permanent but diminished 1-2 days after ketamine withdrawal. Sub-anesthetic post-training doses of ketamine (5 mg/kg) had no effect on memory consolidation, and larger doses (10, 20 and 50 mg/kg) did not influence the retrieval of memory in the T-maze. The data suggest that repeated anesthetic doses of ketamine block NMDA receptors and affect memory consolidation. Moreover, NMDA mechanisms antagonized by ketamine appear to be selectively involved in spatial (T-maze) memory mechanisms but may not be necessary for non-spatial (passive avoidance) memory consolidation. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the National Science Foundation of China (NSFC 30470553 and 30530270) and the Program of the Chinese Academy of Science. |
| 原文出处 | 2006140993.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5449]  |
| 专题 | 昆明动物研究所_认知障碍病理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_神经系统编码 |
| 作者单位 | 1.Section of Cognitive Brain Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zool- ogy, Chinese Academy of Sciences, Kunming, Yunnan 650223, PR China 2.Graduate School of Chinese Academy of Sciences, Beijng, PR China |
| 推荐引用方式 GB/T 7714 | Wang JH,Fu Y,Wilson FAW[*],et al. Ketamine affects memory consolidation: Differential effects in T-maze and passive avoidance paradigms in mice[J]. NEUROSCIENCE,2006,140(3):993-1002. |
| APA | Wang JH,Fu Y,Wilson FAW[*],&Ma YY[*].(2006).Ketamine affects memory consolidation: Differential effects in T-maze and passive avoidance paradigms in mice.NEUROSCIENCE,140(3),993-1002. |
| MLA | Wang JH,et al."Ketamine affects memory consolidation: Differential effects in T-maze and passive avoidance paradigms in mice".NEUROSCIENCE 140.3(2006):993-1002. |
入库方式： OAI收割
来源：昆明动物研究所
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