Effects of scopolamine on morphine-induced conditioned place preference in mice
文献类型：期刊论文
| 作者 | Tan H1,2,3,4; Liu N1,2,3; Wilson FAW1,2,3; Ma YY[*]1,2,3 |
| 刊名 | ADDICTION BIOLOGY
 |
| 出版日期 | 2007 |
| 卷号 | 12期号:3-4页码:463-469 |
| 关键词 | cholinergic system conditioned place preference learning and memory mice morphine scopolamine |
| ISSN号 | 1355-6215 |
| 通讯作者 | yuanma@hotmail.com |
| 合作状况 | 其它 |
| 英文摘要 | It is well known that the cholinergic system plays a crucial role in learning and memory. Psychopharmacological studies in humans and animals have shown that a systemic cholinergic blockade may induce deficits in learning and memory. Accumulated studies have indicated that learning and memory play an important role in drug addition. In the present study, in order to get a further understanding about the functions of the cholinergic system in drug-related learning and memory, we examined the effects of scopolamine (0.5, 1.0 and 2.0 mg/kg) on morphine-induced conditioned place preference (CPP). Two kinds of morphine exposure durations (4 days and 12 days) were used. The main finding was that all doses of scopolamine enhanced the extinction of morphine-induced CPP in mice treated with morphine for 12 days. However, in mice treated with morphine for 4 days, all doses of scopolamine did not inhibit morphine-induced CPP. The highest dose (2.0 mg/kg) of scopolamine even significantly delayed the extinction of morphine-induced CPP. Our results suggest that the effects of a systemic cholinergic blockade on morphine-induced CPP depend on the morphine exposure time. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by Key Technologies R&D Program (2006038022021), National Natural Science Foundation of China (NSFC 30470553 and 30530270), 973 program (2005CB522803), and the Chinese Acad- emy of Science Grants (KSCX2-SW-217-03). We thank Mr Sun for his assistance. |
| 原文出处 | 200712463.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5459]  |
| 专题 | 昆明动物研究所_认知障碍病理学 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.Kunming Institute of Zoology 2.Kunming Primate Research Center,Chinese Academy of Sciences, 3.Graduate University of Chinese Academy of Sciences, China 4.College of Mechanical and Electrical Engineering, Nanjing University of Aeronautics and Astronautics, China |
| 推荐引用方式 GB/T 7714 | Tan H,Liu N,Wilson FAW,et al. Effects of scopolamine on morphine-induced conditioned place preference in mice[J]. ADDICTION BIOLOGY,2007,12(3-4):463-469. |
| APA | Tan H,Liu N,Wilson FAW,&Ma YY[*].(2007).Effects of scopolamine on morphine-induced conditioned place preference in mice.ADDICTION BIOLOGY,12(3-4),463-469. |
| MLA | Tan H,et al."Effects of scopolamine on morphine-induced conditioned place preference in mice".ADDICTION BIOLOGY 12.3-4(2007):463-469. |
入库方式： OAI收割
来源：昆明动物研究所
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