Spatial and temporal sensitivity degradation of primary visual cortical cells in senescent rhesus monkeys
文献类型：期刊论文
| 作者 | Zhang J1,2,3; Wang XS1,2,3; Wang YC4,5; Fu Y1,2,3; Liang Z4; Ma YY[*]1,2; Leventhal AG[*]4,5 |
| 刊名 | EUROPEAN JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2008 |
| 卷号 | 28期号:1页码:201-207 |
| 关键词 | aging central visual pathway degradation intracortical inhibition spatial and temporal sensitivities visual function |
| ISSN号 | 0953-816X |
| 通讯作者 | yuanma0716@vip.sina.com ; audie.leventhal@m.cc.utah.edu |
| 合作状况 | 其它 |
| 英文摘要 | Human visual function declines with age. Much of this decline is mediated by changes in the central visual pathways. In this study we compared the spatial and temporal sensitivities of striate cortical cells in young and old paralysed macaque monkeys. Extracellular single-unit recordings were employed. Our results show that cortical neurons in old monkeys exhibit lower optimal spatial and temporal frequencies, lower spatial resolution and lower high temporal frequency cut-offs than do cells in young adult monkeys. These changes in old monkeys are accompanied by increased visually evoked responses, increased spontaneous activities and decreased signal-to-noise ratios. The increased excitability of cells in old animals is consistent with an age-related degeneration of intracortical inhibition. The degradation of spatial and temporal function in old striate cortex should contribute to the decline in visual function that accompanies normal aging. |
| 学科主题 | Neurosciences |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from NIH ⁄ NIA R01 AG 17922, the Natural Science Foundation of China (30520120072 and 30670669), National Basic Research Program (2006CB500804), the Foundation of Chinese Academy of Sciences (KSCX2-SW-217), 973 Program (2007CB947703) |
| 原文出处 | 200828201.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5467]  |
| 专题 | 昆明动物研究所_认知障碍病理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.Section of Primate Neuroscience Research, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Kunming, Yunnan, China 2.Kunming Primate Center, Chinese Academy of Sciences, Kunming, Yunnan, China 3.Graduate School of Chinese Academy of Sciences, Beijing, China 4.Department of Neurobiology and Biophysics, University of Science and Technology of China, Hefei, Anhui, China 5.Department of Neurobiology and Anatomy, School of Life Science, University of Utah, Salt Lake City, UT 84132, USA |
| 推荐引用方式 GB/T 7714 | Zhang J,Wang XS,Wang YC,et al. Spatial and temporal sensitivity degradation of primary visual cortical cells in senescent rhesus monkeys[J]. EUROPEAN JOURNAL OF NEUROSCIENCE,2008,28(1):201-207. |
| APA | Zhang J.,Wang XS.,Wang YC.,Fu Y.,Liang Z.,...&Leventhal AG[*].(2008).Spatial and temporal sensitivity degradation of primary visual cortical cells in senescent rhesus monkeys.EUROPEAN JOURNAL OF NEUROSCIENCE,28(1),201-207. |
| MLA | Zhang J,et al."Spatial and temporal sensitivity degradation of primary visual cortical cells in senescent rhesus monkeys".EUROPEAN JOURNAL OF NEUROSCIENCE 28.1(2008):201-207. |
入库方式： OAI收割
来源：昆明动物研究所
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