Extremely low-frequency electromagnetic field exposure during chronic morphine treatment strengthens downregulation of dopamine D2 receptors in rat dorsal hippocampus after morphine withdrawal
文献类型：期刊论文
| 作者 | Wang XS1,2,3; Liu YD4; Lei YL1,3; Zhou DM3,5; Fu Y1,3; Che Y1,3,6; Xu RC7; Yu HL4; Hu XT2,8; Ma YY[*]1 |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2008 |
| 卷号 | 433期号:3页码:178-182 |
| 关键词 | D2 receptors electromagnetic field immunohistochemistry dorsal hippocampus morphine rats |
| ISSN号 | 0304-3940 |
| 通讯作者 | yuanma07l6@vip.sina.com |
| 合作状况 | 其它 |
| 英文摘要 | The aim of this study was to investigate the effect of extremely low-frequency electromagnetic field (ELF-EMF) exposure during morphine treatment on dopamine D2 receptor (D2R) density in the rat dorsal hippocampus following withdrawal. Rats were exposed to ELF-EMF (20 Hz, 14 mT) or sham exposed for 1 h per day before injection of morphine (10 mg/kg, i.p.) once daily for 12 days. The saline control group was sham exposed for the same period. Immunohistochemistry was used to detect the density of D2Rs on the 1st, 3rd and 5th morphine withdrawal days. The results showed that the density of D2Rs in sham-exposed morphine-treated rats on the 1st and 3rd days of morphine withdrawal was significantly lower than that of the saline control group. The ELF-EMF-exposed morphine group also exhibited a significantly lower density of D2Rs on the 1st and 3rd withdrawal days relative to the sham-exposed morphine group. However, the D2R density in both groups tended to recover as morphine withdrawal days increased. The results suggest that dorsal hippocampal D2Rs are sensitive to morphine withdrawal and that this is potentiated by ELF-EMF pre-exposure during morphine treatment. (C) 2008 Elsevier Ireland Ltd. All rights reserved. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), 973 Program (2005CB522803, 2007CB947703), 863 Program (O7013810, 2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese-Finnish International CollaborationProject-neuro(30621130076),ProgramofCASC (KSCX1-YW-R-33, YZ200737), National Key Technologies R&D Program and Yunnan Science and Technique Program (2006PT08-2). |
| 原文出处 | 2008433178.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5473]  |
| 专题 | 昆明动物研究所_认知障碍病理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_神经系统编码 |
| 作者单位 | 1.Laboratory of Primate Neuroscience Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, #32 Jiao Chang Dong Lu, Kunming, Yunnan, 650223, P. R. China 2.Laboratory of Sensory-motor Integration Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, #32 Jiao Chang Dong Lu, Kunming, Yunnan, 650223, P. R. China 3.Graduate University of Chinese Academy of Sciences, Beijing, 100049, P. R. China 4.Department of Neurosurgery, First Affiliated Hospital of Kunming Medical School, Kunming, Yunnan, 650032, P. R. China 5.The Institute of Biophysics of the Chinese Academy of Sciences, Beijing, 100101, P. R. China 6.School of Life Science, Suzhou University, Suzhou , Jiangsu, 215006, P. R. China 7.Department of Endocrine, Second Affiliated Hospital of Kunming Medical School, Kunming, Yunnan, 650101, P. R. China 8.Shanghai Institute of Brain Functional Genomics, East China Normal University, Shanghai, 200062, P. R. China |
| 推荐引用方式 GB/T 7714 | Wang XS,Liu YD,Lei YL,et al. Extremely low-frequency electromagnetic field exposure during chronic morphine treatment strengthens downregulation of dopamine D2 receptors in rat dorsal hippocampus after morphine withdrawal[J]. NEUROSCIENCE LETTERS,2008,433(3):178-182. |
| APA | Wang XS.,Liu YD.,Lei YL.,Zhou DM.,Fu Y.,...&Ma YY[*].(2008).Extremely low-frequency electromagnetic field exposure during chronic morphine treatment strengthens downregulation of dopamine D2 receptors in rat dorsal hippocampus after morphine withdrawal.NEUROSCIENCE LETTERS,433(3),178-182. |
| MLA | Wang XS,et al."Extremely low-frequency electromagnetic field exposure during chronic morphine treatment strengthens downregulation of dopamine D2 receptors in rat dorsal hippocampus after morphine withdrawal".NEUROSCIENCE LETTERS 433.3(2008):178-182. |
入库方式： OAI收割
来源：昆明动物研究所
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