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Chronic morphine selectively impairs cued fear extinction in rats: Implications for anxiety disorders associated with opiate use

文献类型：期刊论文

作者Gu CL1; Li P2; Hu B1; Ouyang XP1; Fu J1; Gao J1; Song Z1; Han L1; Ma YY[*]3; Tian SW[*]1
刊名NEUROPSYCHOPHARMACOLOGY
出版日期2008
卷号33期号:3页码:666-673
关键词anxiety disorders amygdala rats prefrontal cortex chronic morphine fear extinction
ISSN号0893-133X
通讯作者tsw.neuro@126.com ; xhu@mail.kiz.ac.cn
合作状况其它
中文摘要Previous studies have shown that opioid transmission plays an important role in learning and memory. However, little is known about the course of opiate-associated learning and memory deficits after cessation of chronic opiate use in a behavioral animal model. In the present study, we examined the effects of chronic morphine on fear extinction, an important preclinical model for behavior therapy of human anxiety disorders. Rats were administrated subcutaneously morphine hydrochloride or saline twice per day for continuous 10 days. Rats received a cued or contextual fear conditioning session 7 days after the last morphine injection. During subsequent days, rats received four cued or contextual extinction sessions ( one session per day). Percent freezing was assessed during all phases of training. Chronic morphine did not affect the acquisition of cued fear response or the initial encoding of extinction memory within each session, but produced an impairment in the between-session extinction. However, the same morphine treatment schedule did not affect the acquisition or extinction of contextual fear response. These results suggest that the effects of chronic morphine on memory for fear extinction are complex. Chronic morphine selectively impairs extinction of cued fear response. This deficit in fear extinction may be one of those critical components that contribute to the high prevalence of anxiety disorders in opiate addicts.
收录类别SCI
资助信息This study was supported by A Project Supported by Scientific Research Fund of Hunan Provincial Education Department (05B045), National Basic Research Program of China (2002CB410803-04), Nanhua University Doctor Foun- dation (5-03-XJQ-03-041), Chinese Academy of Sciences Grants (KSCX2-SW), National Basic Research Program of China, Chinese Science Foundation (30470553), and Program of Chinese Academy of Sciences (KJCX1-01).
原文出处200833666.pdf
语种英语
公开日期2010-08-24
源URL[http://159.226.149.42:8088/handle/152453/5481]  
专题昆明动物研究所_认知障碍病理学
昆明动物研究所_神经系统编码
作者单位1.Department of Physiology, College of Medicine, Nanhua University, Hengyang, Hunan, PR China
2.Department of Biology, College of Life Science and Technology, Nanhua University, Hengyang, Hunan, PR China
3.Laboratory of Primate Cognitive Neuroscience, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, PR China
推荐引用方式
GB/T 7714		 Gu CL,Li P,Hu B,et al. Chronic morphine selectively impairs cued fear extinction in rats: Implications for anxiety disorders associated with opiate use[J]. NEUROPSYCHOPHARMACOLOGY,2008,33(3):666-673.
APA Gu CL.,Li P.,Hu B.,Ouyang XP.,Fu J.,...&Hu XT[*].(2008).Chronic morphine selectively impairs cued fear extinction in rats: Implications for anxiety disorders associated with opiate use.NEUROPSYCHOPHARMACOLOGY,33(3),666-673.
MLA Gu CL,et al."Chronic morphine selectively impairs cued fear extinction in rats: Implications for anxiety disorders associated with opiate use".NEUROPSYCHOPHARMACOLOGY 33.3(2008):666-673.

入库方式： OAI收割

来源：昆明动物研究所

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