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Distracters Impair and Create Working Memory-Related Neuronal Activity in the Prefrontal Cortex

文献类型：期刊论文

作者Artchakov D1; Tikhonravov D1; Ma YY2; Neuvonen T1; Linnankoski I1; Carlson S[*]1,3,4
刊名CEREBRAL CORTEX
出版日期2009
卷号19期号:11页码:2680-2689
关键词delayed matching to sample distraction primate single cell working memory
ISSN号1047-3211
通讯作者syncarls@cc.helsinki.fi
合作状况其它
英文摘要The prefrontal cortex (PFC) has a central role in working memory (WM). Resistance to distraction is considered a fundamental feature of WM and PFC neuronal activity. However, although unexpected stimuli often disrupt our work, little is known about the underlying neuronal mechanisms involved. In the present study, we investigated whether irregularly presented distracters disrupt WM task performance and underlying neuronal activity. We recorded single neuron activity in the PFC of 2 monkeys performing WM tasks and investigated effects of auditory and visual distracters on WM performance and neuronal activity. Distracters impaired memory task performance and affected PFC neuronal activity. Distraction that was of the same sensory modality as the memorandum was more likely to impair WM performance and interfere with memory-related neuronal activity than information that was of a different sensory modality. The study also shows that neurons not involved in memory processing in less demanding conditions may become engaged in WM processing in more demanding conditions. The study demonstrates that WM performance and underlying neuronal activity are vulnerable to irregular distracters and suggests that the PFC has mechanisms that help to compensate for disruptive effects of external distracters.
学科主题Neurosciences
收录类别SCI
资助信息Academy of Finland (National Centers of Excellence Program 2006--2011 and Chinese--Finnish Collaboration of the Neuro Program No. 214412); National Science Foundation of China (Chinese--Finnish International Collaboration, Project-neuro No. 30621130076, 30530270)
原文出处200919112680.pdf
语种英语
公开日期2010-08-24
源URL[http://159.226.149.42:8088/handle/152453/5487]  
专题昆明动物研究所_认知障碍病理学
作者单位1.Neuroscience Unit, Institute of Biomedicine/Physiology and Department of Basic Veterinary Sciences/Physiology, University of Helsinki, Finland
2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
3.Medical School, University of Tampere, Tampere, Finland
4.Brain Research Unit, Low Temperature Laboratory, Helsinki University of Technology, Espoo, Finland
推荐引用方式
GB/T 7714		 Artchakov D,Tikhonravov D,Ma YY,et al. Distracters Impair and Create Working Memory-Related Neuronal Activity in the Prefrontal Cortex[J]. CEREBRAL CORTEX,2009,19(11):2680-2689.
APA Artchakov D,Tikhonravov D,Ma YY,Neuvonen T,Linnankoski I,&Carlson S[*].(2009).Distracters Impair and Create Working Memory-Related Neuronal Activity in the Prefrontal Cortex.CEREBRAL CORTEX,19(11),2680-2689.
MLA Artchakov D,et al."Distracters Impair and Create Working Memory-Related Neuronal Activity in the Prefrontal Cortex".CEREBRAL CORTEX 19.11(2009):2680-2689.

入库方式： OAI收割

来源：昆明动物研究所

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