中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Pentylenetetrazole-induced status epilepticus following training does not impair expression of morphine-induced conditioned place preference

文献类型:期刊论文

作者Zhang J1,3; Tan H4; Niu HC1,2; Wang JH1,3; Tang XD5; Sanford LD5; Ma YY[*]1,2
刊名ADDICTION BIOLOGY
出版日期2009
卷号14期号:2页码:174-184
关键词Conditioned place preference learning and memory morphine Morris water maze status epilepticus Y-maze
ISSN号1355-6215
通讯作者yuanma0716@vip.sina.com
合作状况其它
英文摘要Learning and memory play an important role in morphine addiction. Status epilepticus (SE) can impair the spatial and emotional learning and memory. However, little is known about the effects of SE on morphine-induced conditioned place preference (CPP). The present study was designed to investigate the effects of SE on morphine CPP, with food CPP being used as a control. The effects of SE on spatial memory in the Morris water maze (MWM) and Y-maze were investigated. SE was induced in adult mice using intraperitoneal injection of pentylenetetrazole; control mice received saline. The data indicated that SE had no effects on the formation of morphine CPP; however, the formation of food CPP was blocked by SE. Meanwhile, spatial memory assayed in the MWM and Y-maze was impaired by SE. In addition, the data demonstrated that SE did not cause a lasting disturbance of motor activity nor a change in the mice's appetite. These results suggested that although SE had no effects on morphine CPP, there was impaired food CPP and spatial memory in both the MWM and the Y-maze. The mechanisms underlying memory process of morphine CPP may be different from other types of memory.
收录类别SCI
资助信息This study was supported by National Science Foundation of China (NSFC 30470553, 30770700 and 30530270), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810), Chinese- Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33) and National Key Technologies R&D Program.
语种英语
公开日期2010-08-24
源URL[http://159.226.149.42:8088/handle/152453/5495]  
专题昆明动物研究所_认知障碍病理学
昆明动物研究所_神经系统编码
昆明动物研究所_中国科学院昆明灵长类研究中心
作者单位1.Laboratory of Primate Neuroscience Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming,Yunnan, China
2.Kunming Primate Center, Chinese Academy of Sciences, Kunming,Yunnan, China
3.Graduate School of Chinese Academy of Sciences,Beijing,China
4.College of Mechanical and Electrical Engineering,Nanjing University of Aeronautics and Astronautics,Nanjing,Jiangsu,China
5.Department of Pathology and Anatomy, EasternVirginia Medical School, USA
推荐引用方式
GB/T 7714
Zhang J,Tan H,Niu HC,et al. Pentylenetetrazole-induced status epilepticus following training does not impair expression of morphine-induced conditioned place preference[J]. ADDICTION BIOLOGY,2009,14(2):174-184.
APA Zhang J.,Tan H.,Niu HC.,Wang JH.,Tang XD.,...&Ma YY[*].(2009).Pentylenetetrazole-induced status epilepticus following training does not impair expression of morphine-induced conditioned place preference.ADDICTION BIOLOGY,14(2),174-184.
MLA Zhang J,et al."Pentylenetetrazole-induced status epilepticus following training does not impair expression of morphine-induced conditioned place preference".ADDICTION BIOLOGY 14.2(2009):174-184.

入库方式: OAI收割

来源:昆明动物研究所

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