Increasing top-down suppression from prefrontal cortex facilitates tactile working memory
文献类型：期刊论文
| 作者 | Hannula H1,2; Neuvonen T1,2,7; Savolainen P1; Hiltunen J3; Ma YY4; Antila H1; Salonen O5; Carlson S[*]1,3,6; Pertovaara A[*]7 |
| 刊名 | NEUROIMAGE
 |
| 出版日期 | 2010 |
| 卷号 | 49期号:1页码:1091-1098 |
| ISSN号 | 1053-8119 |
| 通讯作者 | syncarls@cc.helsinki.fi ; antti.pertovaara@helsinki.fi |
| 合作状况 | 其它 |
| 英文摘要 | Navigated transcranial magnetic stimulation (TMS) combined with diffusion-weighted magnetic resonance imaging (DW-MRI) and tractography allows investigating functional anatomy of the human brain with high precision. Here we demonstrate that working memory (WM) processing of tactile temporal information is facilitated by delivering a single TMS pulse to the middle frontal gyrus (MFG) during memory maintenance. Facilitation was obtained only with a TMS pulse applied to a location of the MFG with anatomical connectivity to the primary somatosensory cortex (S1). TMS improved tactile WM also when distractive tactile stimuli interfered with memory maintenance. Moreover, TMS to the same MFG site attenuated somatosensory evoked responses (SEPs). The results suggest that the TMS-induced memory improvement is explained by increased top-down suppression of interfering sensory processing in S1 via the MFG-S1 link. These results demonstrate an anatomical and functional network that is involved in maintenance of tactile temporal WM. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Research Programme on Neuroscience (project 111699 and Chinese–Finnish project 214412) and the National Center of Excellence Programme of the Academy of Finland, the EVO Programme of the Helsinki University Central Hospital, National Science Foundation of China (Chinese–Finnish International Collaboration, Project-Neuro Nos. 30621130076, 30530270), and the Sigrid Jusélius Foundation, Helsinki, Finland. |
| 原文出处 | 2010491091.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5509]  |
| 专题 | 昆明动物研究所_认知障碍病理学 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.Neuroscience Unit, Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland 2.Nexstim Ltd., Helsinki, Finland 3.Advanced Magnetic Imaging Center, Brain Research Unit, Helsinki University of Technology, Espoo, Finland 4.Kunming Institute of Zoology and Kunming Primate Center, Chinese Academy of Sciences, Kunming, Yunnan, P.R. China 5.Functional Brain Imaging Unit, Helsinki Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland 6.Medical School, University of Tampere, Tampere, Finland 7.Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland |
| 推荐引用方式 GB/T 7714 | Hannula H,Neuvonen T,Savolainen P,et al. Increasing top-down suppression from prefrontal cortex facilitates tactile working memory[J]. NEUROIMAGE,2010,49(1):1091-1098. |
| APA | Hannula H.,Neuvonen T.,Savolainen P.,Hiltunen J.,Ma YY.,...&Pertovaara A[*].(2010).Increasing top-down suppression from prefrontal cortex facilitates tactile working memory.NEUROIMAGE,49(1),1091-1098. |
| MLA | Hannula H,et al."Increasing top-down suppression from prefrontal cortex facilitates tactile working memory".NEUROIMAGE 49.1(2010):1091-1098. |
入库方式： OAI收割
来源：昆明动物研究所
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