Learning large-scale spatial relationships in a maze and effects of MK-801 on retrieval in the rhesus monkey
文献类型：期刊论文
| 作者 | Wang JH1,2,3; Zhang B1,2,3; Meng ZQ1,2,3; Sun NL1,2,3; Ma MX4; Zhang HX1,2; Tang XD5; Sanford LD5; Wilson FAW1,2; Hu XT[*]1,2 |
| 刊名 | DEVELOPMENTAL NEUROBIOLOGY
 |
| 出版日期 | 2007 |
| 卷号 | 67期号:13页码:1731-1741 |
| 关键词 | maze MK-801 rhesus monkey spatial memory working memory |
| ISSN号 | 1932-8451 |
| 通讯作者 | xthu@mail.kiz.ac.cn ; yuanma0716@vip.sina.com |
| 英文摘要 | Monkeys have strong abilities to remember the visual properties of potential food sources for survival in the nature. The present study demonstrated the first observations of rhesus monkeys learning to solve complex spatial mazes in which routes were guided by visual cues. Three monkeys were trained in a maze (6 m x 6 m) included of four different mazes. We recorded the cue and cup errors, latencies, and pathway for each trial. The data showed that monkeys learned the target place after three days in the first maze and spent a shorter time in learning the following mazes. The maze was an efficient method to measure the ability and proceeding of spatial memory in monkeys. Moreover, working memory can also be tested by using the maze. MK-801 at 0.02 mg/kg but not at 0.005 mg/kg impaired monkeys' retrieval of spatial memory after they learned all four mazes. The present maze may provide an efficient method to help bridging the gap in cognition between nonhuman primates and humans, and in particular to gain insight into human cognitive function and dysfunction. |
| 收录类别 | SCI |
| 资助信息 | National Science Foundation of China; contract grant numbers: NSFC 30470553, 30530270. 973 Program; contract grant number: 2005CB522803. Chinese-Finnish International Collabora- tion Project-Neuro; contract grant number: 30621130076. National Key Technologies R&D Pro- gram. the Academy of Finland (National Cen- ter of Excellence Program) and research grant from the University of Helsinki. |
| 原文出处 | 2007671731.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5515]  |
| 专题 | 昆明动物研究所_神经系统编码 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_认知障碍病理学 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.Laboratory of Primate Neuroscience Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, People’s Republic of China 2.Kunming Primate Center, Chinese Academy of Sciences, Kunming, Yunnan, People’s Republic of China 3.Graduate School of Chinese Academy of Sciences, Beijing, People’s Republic of China 4.Department of Psychology, Jilin University, Chang Chun, People’s Republic of China 5.Department of Pathology and Anatomy, Eastern Virginia Medical School, Norfolk, Virginia, U.S.A 6.Neuroscience Unit, Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland and Medical School, University of Tampere, Tampere, Finland |
| 推荐引用方式 GB/T 7714 | Wang JH,Zhang B,Meng ZQ,et al. Learning large-scale spatial relationships in a maze and effects of MK-801 on retrieval in the rhesus monkey[J]. DEVELOPMENTAL NEUROBIOLOGY,2007,67(13):1731-1741. |
| APA | Wang JH.,Zhang B.,Meng ZQ.,Sun NL.,Ma MX.,...&Ma YY[*].(2007).Learning large-scale spatial relationships in a maze and effects of MK-801 on retrieval in the rhesus monkey.DEVELOPMENTAL NEUROBIOLOGY,67(13),1731-1741. |
| MLA | Wang JH,et al."Learning large-scale spatial relationships in a maze and effects of MK-801 on retrieval in the rhesus monkey".DEVELOPMENTAL NEUROBIOLOGY 67.13(2007):1731-1741. |
入库方式： OAI收割
来源：昆明动物研究所
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