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  5. 学习记忆的分子神经机制
Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal

文献类型：期刊论文

作者Sun N1,3; Li Y2,3; Tian S4; Lei Y1,3; Zheng J1,3; Yang J1; Sui N5; Xu L6; Pei G7; Wilson FAW1,8
刊名NEUROSCIENCE
出版日期2006
卷号138期号:1页码:77-82
关键词conditioned place preference manganese- enhanced MRI gamma-band EEG drug craving
ISSN号0306-4522
通讯作者leihao@wipm.ac.cn ; xhu@cns.bcm.tmc.edu
合作状况其它
英文摘要The orbitofrontal cortex is involved in the reinforcing effects of drugs of abuse. However, how the dynamic activity in OFC changes during opiate administration and withdrawal period has not been investigated. We first tested the effects of opiates and drug craving with the conditioned place preference paradigm, using manganese-enhanced magnetic resonance imaging and traditional electroencephalograph recording techniques in rats. T1-weighted 2D MRI (4.7 T) was used after unilateral injection of MnCl(2) (200 nL, 80 mM) into the right orbitofrontal cortex. The manganese-enhanced magnetic resonance imaging data suggested that the OFC activity decreased during the opiate administration period but recovered increasingly during the withdrawal period. Also, we found decreases and increases in gamma-band (20-100 Hz) activity during the opiate administration and withdrawal period, respectively. Our results showed that orbitofrontal cortex activity decreased during morphine administration and then went up progressively over several days during withdrawal. The time course of the recovery of orbitofrontal activity from inhibition during the withdrawal period may be related to the experience of drug craving.
收录类别SCI
资助信息This work was supported by Chinese Acad- emy of Science Grants (KSCX2-SW for M.Y.), National Basic Research Program of China, Chinese National Science Founda- tion (30470553, 10234070, and 30370419) and Program of Chi- nese Academy of Science (KJCX1-01).
原文出处200613877.pdf
语种英语
公开日期2010-08-24
源URL[http://159.226.149.42:8088/handle/152453/5897]  
专题昆明动物研究所_学习记忆的分子神经机制
昆明动物研究所_认知障碍病理学
昆明动物研究所_神经系统编码
作者单位1.Laboratory of Primate Cognitive Neuroscience, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, PR China
2.State Key Laboratory of Magnetic Resonance and Atomic and Mo- lecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 43007, PR China
3.Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China
4.Medical School of Nanhua University, 412000 Hunan, PR China
5.The Key Laboratory of Mental Health, Institute of Psychology, The Chinese Academy of Sciences, Beijing 100101, PR China
6.Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, PR China
7.Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Chinese Academy of Sciences, Shanghai 200031, PR China
8.Departments of Psychology and Neurology, University of Arizona, Tucson, AZ, USA
推荐引用方式
GB/T 7714		 Sun N,Li Y,Tian S,et al. Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal[J]. NEUROSCIENCE,2006,138(1):77-82.
APA Sun N.,Li Y.,Tian S.,Lei Y.,Zheng J.,...&Hu X[*].(2006).Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal.NEUROSCIENCE,138(1),77-82.
MLA Sun N,et al."Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal".NEUROSCIENCE 138.1(2006):77-82.

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来源：昆明动物研究所

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