Effects of beta-adrenergic antagonist, propranolol on spatial memory and exploratory behavior in mice
文献类型：期刊论文
| 作者 | Sun HY1; Mao Y1,2; Wang JH1; Ma YY[*]1,3 |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2011 |
| 卷号 | 498期号:2页码:133-137 |
| 关键词 | Propranolol Y-maze Mice Spatial memory Acquisition |
| 通讯作者 | yuanma0716@vip.sina.com |
| 合作状况 | 其它 |
| 英文摘要 | The beta-adrenergic system has been suggested to be involved in novelty detection and memory modulation. The present study aimed to investigate the role of beta-adrenergic receptors on novelty-based spatial recognition memory and exploratory behavior in mice using Y-maze test and open-field respectively. Mice were injected with three doses of beta-adrenergic receptor antagonist, propranolol (2, 10 and 20 mg/kg) or saline at three different time points (15 min prior to training, immediately after training and 15 min before test). The results showed that higher doses of propranolol (10 and 20 mg/kg) given before the training trial impaired spatial recognition memory while those injected at other two time points did not. A detailed analysis of exploratory behavior in open-field showed that lower dose (2 mg/kg) of propranolol reduced exploratory behavior of mice. Our findings indicate that higher dose of propranolol can impair acquisition of spatial information in the Y-maze without altering locomotion, suggesting that the beta-adrenergic system may be involved in modulating memory processes at the time of learning. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by National Science Foundation of China (NSFC 30770700), the Major State Basic Research of China (NO2003CB716600). |
| 语种 | 英语 |
| 公开日期 | 2011-08-09 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6636]  |
| 专题 | 昆明动物研究所_认知障碍病理学 昆明动物研究所_神经系统编码 |
| 作者单位 | 1.State Key Laboratory of Brain and Cognitive Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, PR China 2.Graduate University of Chinese Academy of Sciences, Beijing 100049, PR China 3.State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, PR China |
| 推荐引用方式 GB/T 7714 | Sun HY,Mao Y,Wang JH,et al. Effects of beta-adrenergic antagonist, propranolol on spatial memory and exploratory behavior in mice[J]. NEUROSCIENCE LETTERS,2011,498(2):133-137. |
| APA | Sun HY,Mao Y,Wang JH,&Ma YY[*].(2011).Effects of beta-adrenergic antagonist, propranolol on spatial memory and exploratory behavior in mice.NEUROSCIENCE LETTERS,498(2),133-137. |
| MLA | Sun HY,et al."Effects of beta-adrenergic antagonist, propranolol on spatial memory and exploratory behavior in mice".NEUROSCIENCE LETTERS 498.2(2011):133-137. |
入库方式： OAI收割
来源：昆明动物研究所
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