Maternal separation produces lasting changes in cortisol and behavior in rhesus monkeys
文献类型：期刊论文
| 作者 | Feng XL1,2,3; Wang LN1,2,3; Yang SC1,2; Qin DD1,2,3; Wang JH1,2; Li CL1,2,3; Lv LB2,4; Ma YY[*]1,2,5; Hu XT[*]1,2,5 |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2011 |
| 卷号 | 108期号:34页码:14312-14317 |
| 关键词 | time profile unbound fraction of cortisol activity repetitive action social affiliative behavior |
| 产权排序 | We thank the radioimmuno-laboratory of the sec- ond affiliated hospital of Kunming Medical College for technical assis- tance. This study was funded by the National Science Foundation of China (NSFC 30770700, 30670669, 30870825, 30530270, 31070963, and 31070965), the 973 program (2007CB947703 and 2011CB707800), the Key Program of the Chinese Academy of Sciences, China (KSCX2-EW-J-23, KSCX2-YW-R-261, and KSCX2-EW-R-11), the West Light Foundation of the Chinese Academy of Sciences (0902351081), the National Natural Science Foundation of China (30921064), and the project sponsored by Yunnan Development and Reform Commission (2009-1988). |
| 通讯作者 | yuanma0716@vip.sina.com ; xthu@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Maternal separation (MS), which can lead to hypothalamic pituitary adrenal axis dysfunction and behavioral abnormalities in rhesus monkeys, is frequently used to model early adversity. Whether this deleterious effect on monkeys is reversible by later experience is unknown. In this study, we assessed the basal hair cortisol in rhesus monkeys after 1.5 and 3 y of normal social life following an early separation. These results showed that peer-reared monkeys had significantly lower basal hair cortisol levels than the mother-reared monkeys at both years examined. The plasma cortisol was assessed in the monkeys after 1.5 y of normal social life, and the results indicated that the peak in the peer-reared cortisol response to acute stressors was substantially delayed. In addition, after 3 y of normal social life, abnormal behavioral patterns were identified in the peer-reared monkeys. They showed decreases in locomotion and initiated sitting together, as well as increases in stereotypical behaviors compared with the mother-reared monkeys. These results demonstrate that the deleterious effects of MS on rhesus monkeys cannot be compensated by a later normal social life, suggesting that the effects of MS are long-lasting and that the maternal-separated rhesus monkeys are a good animal model to study early adversity and to investigate the development of psychiatric disorders induced by exposure to early adversity. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2011-09-14 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6759]  |
| 专题 | 昆明动物研究所_中国科学院昆明灵长类研究中心 昆明动物研究所_认知障碍病理学 昆明动物研究所_神经系统编码 |
| 作者单位 | 1.State Key Laboratory of Brain and Cognitive Science 2.Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, Yunnan 650223, People’s Republic of China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100049, People’s Republic of China 4.Kunming Primate Research Center of the Chinese Academy of Sciences, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, Yunnan 650223, People’s Republic of China 5.Institute of Biophysics, the Chinese Academy of Sciences, Beijing 100101, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Feng XL,Wang LN,Yang SC,et al. Maternal separation produces lasting changes in cortisol and behavior in rhesus monkeys[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2011,108(34):14312-14317. |
| APA | Feng XL.,Wang LN.,Yang SC.,Qin DD.,Wang JH.,...&Hu XT[*].(2011).Maternal separation produces lasting changes in cortisol and behavior in rhesus monkeys.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,108(34),14312-14317. |
| MLA | Feng XL,et al."Maternal separation produces lasting changes in cortisol and behavior in rhesus monkeys".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108.34(2011):14312-14317. |
入库方式： OAI收割
来源：昆明动物研究所
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