心得安对ICR小鼠吗啡诱导的条件化位置偏爱记忆获得和提取的影响
文献类型：期刊论文
| 作者 | 毛羽1,3; 杨上川1; 刘畅1,3; 马原野[*]1,2; 胡新天[*]1,2 |
| 刊名 | 动物学研究
 |
| 出版日期 | 2011 |
| 卷号 | 32期号:6页码:670-674 |
| 关键词 | β-肾上腺素受体 记忆 获得 提取 阿片类物质 条件化位置偏爱 |
| 其他题名 | Effects of propranolol on acquisition and retrieval of morphine- induced conditioned place preference memories in ICR mice |
| 通讯作者 | yuanma0716@vip.sina.com ; xthu@mail.kiz.ac.cn |
| 中文摘要 | 利用心得安阻断beta-肾上腺素受体(beta-受体)，从而干扰药物成瘾患者对药物环境线索记忆的某些环节(如再巩固等)，进而降低或抑制其对成瘾药物的渴求，已成为未来治疗复吸的潜在途径。但目前，心得安对吗啡相关环境线索记忆的获得及提取的影响尚不清楚。因此，该实验检测了心得安对小鼠吗啡诱导的条件化位置偏爱(conditioned place preference，CPP)环境线索记忆的获得和提取的影响。该研究首次发现在吗啡CPP记忆的获得期，心得安不影响CPP的表达和消退，提示beta-受体不参与吗啡诱导CPP学习记忆的获得；而在吗啡CPP记忆的提取期，心得安可延缓CPP的消退，提示beta-受体与吗啡诱导CPP学习记忆的提取相关。该结果表明，药物成瘾过程与beta-受体相关，为成瘾等精神疾病的治疗提供了新的理论依据。 |
| 英文摘要 | To interfere with the drug-cue memory processes of addicts such as reconsolidation by the administration of the β-adrenergic receptor (β-AR) of norepinephrine (NE) antagonist propranolol (PRO) has become a potential therapy in the future to decrease or inhibit relapse. However, the relationship between PRO and the acquisition or retrieval of morphine-cue memory is not clear. This study examined the effects of PRO on the acquisition and retrieval of memories in morphine-induced conditioned place preference (CPP) mice model. We found that during memory acquisition period, PRO had no effects on the expression and extinction of morphine-CPP, which suggests that the β-AR was irrelevant to the CPP memory acquisition. However, during memory retrieval period, although PRO did not affect the expression of CPP, but it delayed the occurrence of CPP extinction, which indicates that PRO has an inhibit effect on CPP memory extinction, and β-AR plays an important role in modulating the extinction of morphine-CPP. Our study further improved the relationship between drug addiction and β-AR, and proposed a new theory to help developing potential therapy to cure addiction and other neuropsychiatric disorders. |
| 收录类别 | 其他 |
| 资助信息 | 国家自然基金面上项目(30870825). |
| 语种 | 中文 |
| 公开日期 | 2012-05-10 |
| 源URL | [http://159.226.149.42:8088/handle/152453/6936]  |
| 专题 | 昆明动物研究所_神经系统编码 昆明动物研究所_认知障碍病理学 |
| 作者单位 | 1.中国科学院昆明动物研究所, 云南 昆明 650223 2.中国科学院生物物理研究所 脑与认知国家重点实验室, 北京 100011 3.中国科学院研究生院, 北京 100049 |
| 推荐引用方式 GB/T 7714 | 毛羽,杨上川,刘畅,等. 心得安对ICR小鼠吗啡诱导的条件化位置偏爱记忆获得和提取的影响[J]. 动物学研究,2011,32(6):670-674. |
| APA | 毛羽,杨上川,刘畅,马原野[*],&胡新天[*].(2011).心得安对ICR小鼠吗啡诱导的条件化位置偏爱记忆获得和提取的影响.动物学研究,32(6),670-674. |
| MLA | 毛羽,et al."心得安对ICR小鼠吗啡诱导的条件化位置偏爱记忆获得和提取的影响".动物学研究 32.6(2011):670-674. |
入库方式： OAI收割
来源：昆明动物研究所
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