Effect of morphine on conditioned place preference in rhesus monkeys
文献类型：期刊论文
| 作者 | Wang JH[*]1; Wu XJ1,2; Li CY1; Wei JK1,2; Jiang HH1,2; Liu CR1,2; Yu CY1; Carlson S3,4,5; Hu XT1,6; Ma H1,2 |
| 刊名 | ADDICTION BIOLOGY
 |
| 出版日期 | 2012 |
| 卷号 | 17期号:3页码:539-546 |
| 关键词 | Addiction conditioning memory morphine place preference rhesus monkey |
| 通讯作者 | wjh16@hotmail.com ; yuanma0716@vip.sina.com |
| 合作状况 | 其它 |
| 英文摘要 | In rodents, a conditioned place preference (CPP) can be induced by morphine. In the current study, we designed a biased place conditioning paradigm to test the rewarding effects of morphine in freely moving rhesus monkeys. Five monkeys were first placed in three serial rooms with the doors open between them for three days. After this habituation period, during which baseline preference for each of the two end rooms was measured, CPP conditioning occurred when the monkeys were injected intramuscularly with morphine at an increasing dose (1.5, 3, 4.5 mg/kg) before they entered the non-preferred room and on alternate days, with saline before they entered the preferred room. Morphine and saline treatment lasted for six days, respectively. CPP was tested 24 hours after the end of CPP training. The result showed that in all five monkeys, CPP was induced by the morphine treatment. The preference lasted for at least 15.3 +/- 1.7 months. |
| 收录类别 | SCI |
| 资助信息 | The authors thank Dr Ilkka Linnankoski and Prof Jean- François Riou for revising the language. This study was supported by National Science Foundation of China the Academy of Finland (National Center of Excellence 2006-11 and the Neuro Program 214412). |
| 语种 | 英语 |
| WOS记录号 | WOS:000302998400004 |
| 公开日期 | 2012-05-10 |
| 源URL | [http://159.226.149.42:8088/handle/152453/6944]  |
| 专题 | 昆明动物研究所_认知障碍病理学 昆明动物研究所_神经系统编码 |
| 作者单位 | 1.State Key Laboratory of Brain and Cognitive Science, Kunming Institute of Zoology, Chinese Academy of Sciences, China 2.Graduate School of Chinese Academy of Sciences, China 3., Institute of Biomedicine/Physiology, University of Helsinki, Finland 4.Medical School, University ofTampere, Finland 5.Aalto University School of Science andTechnology, Finland 6.State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, China |
| 推荐引用方式 GB/T 7714 | Wang JH[*],Wu XJ,Li CY,et al. Effect of morphine on conditioned place preference in rhesus monkeys[J]. ADDICTION BIOLOGY,2012,17(3):539-546. |
| APA | Wang JH[*].,Wu XJ.,Li CY.,Wei JK.,Jiang HH.,...&Ma YY[*].(2012).Effect of morphine on conditioned place preference in rhesus monkeys.ADDICTION BIOLOGY,17(3),539-546. |
| MLA | Wang JH[*],et al."Effect of morphine on conditioned place preference in rhesus monkeys".ADDICTION BIOLOGY 17.3(2012):539-546. |
入库方式： OAI收割
来源：昆明动物研究所
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