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The effects of lesion of the olfactory epithelium on morphine-induced sensitization and conditioned place preference in mice

文献类型：期刊论文

作者Niu HC1; Zheng YW2,3; Rizak JD3; Fan YD4; Huang W1; Ma YY[*]2,3; Lei H[*]1
刊名BEHAVIOURAL BRAIN RESEARCH
出版日期2012
卷号233期号:1页码:71-78
关键词Lesion of the olfactory epithelium Morphine Sensitization Conditioned place preference FosB-like protein ZnSO4 effusion
通讯作者yuanma0716@vip.sina.com ; leihao@wipm.ac.cn
合作状况其它
英文摘要Animals attain information about their environment through different sense organs. For example, the dominant external resource about the environment for rodents is obtained through olfaction. Many environmental conditions (stress or enriched environment) are known to affect an animal's susceptibility to drug addiction. However, it is not known how external information is integrated and paired with drug stimuli to develop into addictive behavior. Here, we investigated the effects of olfactory epithelium lesions induced with ZnSO4 effusion (ZnE) on morphine-induced sensitization and conditioned place preference in mice. We found that the lesion of the olfactory epithelium attenuated the repeated morphine (40 mg/kg)-induced behavioral sensitization and morphine-induced conditioned place preference (CPP) behaviors, such as hyper-locomotion during morphine (40 mg/kg) conditioned training. Additionally, the expression of FosB-like proteins, transcription factors associated with behavioral alterations, in the nucleus accumbens of the brain was attenuated in morphine administered mice treated by ZnE. Taken together, these results indicated that lesion of the olfactory epithelium lead to a decrease in morphine sensitization and CPP behavior in mice as well as modulate specific molecular markers of neuroadaption to drugs of abuse. These findings also suggest that olfaction plays an important role in the development of addictive behaviors that can be modulated by external actions. (C) 2012 Elsevier B.V. All rights reserved.
收录类别SCI
资助信息This work was supported by a 973 program of the Ministry of Sci- ence and Technology of China (2011CB707802) and Natural Science Foundation of China grant 81171302.
语种英语
WOS记录号WOS:000306209500009
公开日期2012-09-04
源URL[http://159.226.149.42:8088/handle/152453/7019]  
专题昆明动物研究所_认知障碍病理学
作者单位1.State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, PR China
2.Yunnan Key Laboratory of Primate Biomedical Research, Kunming 650051, PR China
3.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, PR China
4.Yunnan Province Tumor Hospital, Department of Neurosurgery, Kunming, Yunnan 650106, PR China
推荐引用方式
GB/T 7714		 Niu HC,Zheng YW,Rizak JD,et al. The effects of lesion of the olfactory epithelium on morphine-induced sensitization and conditioned place preference in mice[J]. BEHAVIOURAL BRAIN RESEARCH,2012,233(1):71-78.
APA Niu HC.,Zheng YW.,Rizak JD.,Fan YD.,Huang W.,...&Lei H[*].(2012).The effects of lesion of the olfactory epithelium on morphine-induced sensitization and conditioned place preference in mice.BEHAVIOURAL BRAIN RESEARCH,233(1),71-78.
MLA Niu HC,et al."The effects of lesion of the olfactory epithelium on morphine-induced sensitization and conditioned place preference in mice".BEHAVIOURAL BRAIN RESEARCH 233.1(2012):71-78.

入库方式： OAI收割

来源：昆明动物研究所

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