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A subset of dopamine neurons signals reward for odour memory in Drosophila
文献类型：期刊论文
| 作者 | Liu CQ1,2,3; Placais PY4; Yamagata N1; Pfeiffer BD5; Aso Y1,5; Friedrich AB1; Siwanowicz I1; Rubin GM5; Preat T4; Tanimoto H[*]1 |
| 刊名 | NATURE
 |
| 出版日期 | 2012 |
| 卷号 | 488期号:7412页码:512-+ |
| 通讯作者 | hiromut@neuro.mpg.de |
| 英文摘要 | Animals approach stimuli that predict a pleasant outcome(1). After the paired presentation of an odour and a reward, Drosophila melanogaster can develop a conditioned approach towards that odour(2,3). Despite recent advances in understanding the neural circuits for associative memory and appetitive motivation(4), the cellular mechanisms for reward processing in the fly brain are unknown. Here we show that a group of dopamine neurons in the protocerebral anterior medial (PAM) cluster signals sugar reward by transient activation and inactivation of target neurons in intact behaving flies. These dopamine neurons are selectively required for the reinforcing property of, but not a reflexive response to, the sugar stimulus. In vivo calcium imaging revealed that these neurons are activated by sugar ingestion and the activation is increased on starvation. The output sites of the PAM neurons are mainly localized to the medial lobes of the mushroom bodies (MBs), where appetitive olfactory associative memory is formed(5,6). We therefore propose that the PAM cluster neurons endow a positive predictive value to the odour in the MBs. Dopamine in insects is known to mediate aversive reinforcement signals(5,7-11). Our results highlight the cellular specificity underlying the various roles of dopamine and the importance of spatially segregated local circuits within the MBs. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000307761600037 |
| 公开日期 | 2012-09-11 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7064]  |
| 专题 | 昆明动物研究所_认知障碍病理学 |
| 作者单位 | 1.Max-Planck-Institut fur Neurobiologie, Martinsried82152, Germany 2.Laboratory of Primate Cognitive Neuroscience, Kunming Institute of Zoology, The Chinese Academy of Sciences,Kunming, Yunnan 650223, China 3.Graduate University of the Chinese Academy of Sciences, Beijing 100049, China 4.Genes and Dynamics of Memory Systems, Neurobiology Unit, Centre National de la Recherche Scientifique, E ´ cole Supe ´rieure de Physique et de Chimie Industrielles, 75005 Paris, France 5.Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA |
| 推荐引用方式 GB/T 7714 | Liu CQ,Placais PY,Yamagata N,et al. A subset of dopamine neurons signals reward for odour memory in Drosophila[J]. NATURE,2012,488(7412):512-+. |
| APA | Liu CQ.,Placais PY.,Yamagata N.,Pfeiffer BD.,Aso Y.,...&Tanimoto H[*].(2012).A subset of dopamine neurons signals reward for odour memory in Drosophila.NATURE,488(7412),512-+. |
| MLA | Liu CQ,et al."A subset of dopamine neurons signals reward for odour memory in Drosophila".NATURE 488.7412(2012):512-+. |
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来源：昆明动物研究所
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