Lesion of olfactory epithelium attenuates expression of morphine-induced behavioral sensitization and reinstatement of drug-primed conditioned place preference in mice
文献类型：期刊论文
| 作者 | Niu HC1; Zheng YW2; Huma T2,4; Rizak JD2; Li L3; Wang GM3; Ren H3; Xu LQ3; Yang JZ2; Ma YY[*]2 |
| 刊名 | PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
 |
| 出版日期 | 2013 |
| 卷号 | 103期号:3页码:526-534 |
| 关键词 | Olfaction Morphine Sensitization Conditioned place preference c-Fos ZnSO4 |
| 通讯作者 | yuanma0716@vip.sina.com ; leihao@wipm.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Previous studies have shown that olfactory impairment by disrupting the olfactory epithelium prior to morphine administration attenuated the development addiction-related behaviors. However, it is unclear whether olfactory impairment will affect the expression of already established addiction-related behaviors. To address this issue, mice were conditioned with morphine to induce behavioral sensitization and condition placed preference (CPP). After an abstinence period, the animals were subjected to either an intranasal ZnSO4 effusion (ZnE) or sham treatment with saline. Behavioral sensitization and CPP reinstatement were evaluated 24 h later, as well as the expression of c-Fos protein, a marker of activated neural sites, in brain regions of interest. It was found that ZnE treatment attenuated morphine-induced behavioral sensitization and reinstatement of CPP. Compared to the saline-treated ones, the ZnE-treated animals showed reduced c-Fos expression in the nucleus accumbens (NAc) associated with behavioral sensitization, and in the NAc, cingulate cortex, dentate gyrus, amygdala, lateral hypothalamus and ventral tegmental area associated with CPP reinstatement. Together, these results demonstrated that acute olfactory impairment could attenuate already established addiction-related behaviors and expression of c-Fos in drug addiction related brain regions, perhaps by affecting the coordination between reward and motivational systems in the brain. (c) 2012 Elsevier Inc. All rights reserved. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the 973 program of the Ministry of Science and Technology of China (2011CB707802) and Natural Sci- ence Foundation of China (grant # 81171302). |
| 语种 | 英语 |
| WOS记录号 | WOS:000314792100015 |
| 公开日期 | 2013-03-14 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7275]  |
| 专题 | 昆明动物研究所_认知障碍病理学 |
| 作者单位 | 1.Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 43007, PR China 2.Laboratory of Primate Neurosciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China 3.Kunming General Hospital of Chengdu Military Region, People's Liberation Army, Kunming, Yunnan 650032, PR China 4.Laboratory of Reproductive Neuroendocrinology, Department of Animal Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan |
| 推荐引用方式 GB/T 7714 | Niu HC,Zheng YW,Huma T,et al. Lesion of olfactory epithelium attenuates expression of morphine-induced behavioral sensitization and reinstatement of drug-primed conditioned place preference in mice[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2013,103(3):526-534. |
| APA | Niu HC.,Zheng YW.,Huma T.,Rizak JD.,Li L.,...&Lei H[*].(2013).Lesion of olfactory epithelium attenuates expression of morphine-induced behavioral sensitization and reinstatement of drug-primed conditioned place preference in mice.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,103(3),526-534. |
| MLA | Niu HC,et al."Lesion of olfactory epithelium attenuates expression of morphine-induced behavioral sensitization and reinstatement of drug-primed conditioned place preference in mice".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 103.3(2013):526-534. |
入库方式： OAI收割
来源：昆明动物研究所
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