Regulation of brain activity in the fusiform face and parahippocampal place areas in 7-11-year-old children
文献类型：期刊论文
| 作者 | Vuontela V[*]1; Jiang P1; Tokariev M1; Savolainen P1,2; Ma YY3; Aronen ET4; Fontell T4; Liiri T1; Ahlstrom M1; Salonen O5 |
| 刊名 | BRAIN AND COGNITION
 |
| 出版日期 | 2013 |
| 卷号 | 81期号:2页码:203-214 |
| 关键词 | Attentional modulation Cognitive control Ventral visual cortex Prefrontal cortex n-Back task Functional connectivity |
| 通讯作者 | virve.vuontela@helsinki.fi ; syncarls@mappi.hel-sinki.fi |
| 合作状况 | 其它 |
| 英文摘要 | Developmental studies have demonstrated that cognitive processes such as attention, suppression of interference and memory develop throughout childhood and adolescence. However, little is currently known about the development of top-down control mechanisms and their influence on cognitive performance. In the present study, we used functional magnetic resonance imaging to investigate modulation of activity in the ventral visual cortex in healthy 7-11-year-old children and young adults. The participants performed tasks that required attention to either face (Fs task) or scene (Sf task) images while trying to ignore distracting scene or face images, respectively. A face-selective area in the fusiform gyrus (fusiform face area, FFA) and an area responding preferentially to scene images in the parahippocampal gyrus (parahippocampal place area, PPA) were defined using functional localizers. Children responded slower and less accurately in the tasks than adults. In children, the right FFA was less selective to face images and regulation of activity between the Fs and Sf tasks was weaker compared to adults. In the PPA, selectivity to scenes and regulation of activity, there according to the task demands were comparable between children and adults. During the tasks, children activated prefrontal cortical areas including the middle (MFG) and superior (SFG) frontal gyrus more than adults. Functional connectivity between the right FFA and left MFG was stronger in adults than children in the Fs task. Children, on the other hand, had stronger functional connectivity than adults in the Sf task between the right FFA and right PPA and between right MFG and medial SFG. There were no group differences in the functional connectivity between the PPA and the prefrontal cortex (PFC). Together the results suggest that, in 7-11-year-old children, the FFA is still immature, whereas the selectivity to scenes and regulation of activity in the PPA is comparable to adults. The results also indicated functional immaturity of the PFC in children compared to adults and weaker connectivity between the PFC and the rFFA, explaining the weaker regulation of activity in the rFFA between the Fs and Sf tasks. |
| 收录类别 | SCI |
| 资助信息 | The study was supported by grants from the Academy of Fin- land (National Centers of Excellence Program 2006–2011, Chi- nese-Finnish Collaboration of the Neuro Program No. 214412 and Grant No. 259752), The Finnish Graduate School of Neuroscience, aivoAALTO project, National Science Foundation of China (Chi- nese-Finnish International Collaboration, Project-Neuro Nos. 30621130076, 30530270), Päivikki and Sakari Sohlberg Founda- tion, Sigrid Juselius Foundation, Finnish Cultural Foundation, Cen- tre for International Mobility CIMO and University of Helsinki. |
| 语种 | 英语 |
| WOS记录号 | WOS:000315067600006 |
| 公开日期 | 2013-03-14 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7277]  |
| 专题 | 昆明动物研究所_认知障碍病理学 |
| 作者单位 | 1.Neuroscience Unit, Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland 2.Nexstim Ltd., Elimäenkatu 9, 000510 Helsinki, Finland 3.Kunming Institute of Zoology, Chinese Academy of Science, Kunming, China 4.Institute of Clinical Medicine, Child Psychiatry, Clinic for Children and Adolescents, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland 5.Helsinki Medical Imaging Center, Department of Radiology, Helsinki University Central Hospital, Helsinki, Finland 6.Brain Research Unit, O.V. Lounasmaa Laboratory, Advanced Magnetic Imaging Centre, Aalto University, School of Science, Espoo, Finland 7.School of Medicine, University of Tampere, Tampere, Finland |
| 推荐引用方式 GB/T 7714 | Vuontela V[*],Jiang P,Tokariev M,et al. Regulation of brain activity in the fusiform face and parahippocampal place areas in 7-11-year-old children[J]. BRAIN AND COGNITION,2013,81(2):203-214. |
| APA | Vuontela V[*].,Jiang P.,Tokariev M.,Savolainen P.,Ma YY.,...&Carlson S[*].(2013).Regulation of brain activity in the fusiform face and parahippocampal place areas in 7-11-year-old children.BRAIN AND COGNITION,81(2),203-214. |
| MLA | Vuontela V[*],et al."Regulation of brain activity in the fusiform face and parahippocampal place areas in 7-11-year-old children".BRAIN AND COGNITION 81.2(2013):203-214. |
入库方式： OAI收割
来源：昆明动物研究所
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