Age- and gender-related metabonomic alterations in striatum and cerebellar cortex in rats
文献类型：期刊论文
| 作者 | Zhang XR[*]1; Wu JF2; Liu HL2,3; Zhang X2 |
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2013 |
| 卷号 | 1507期号:X页码:28-34 |
| 关键词 | NMR Metabonomic Striatum Cerebellar cortex Partial least squares-discriminant analysis |
| 通讯作者 | xianrongzh@yahoo.com |
| 合作状况 | 其它 |
| 英文摘要 | In order to identify the neurochemical alterations in motor associated subcortical nuclei, and enhance our understanding of neurophysiology of progressive reduction in fine motor control with aging, the metabolic changes in striatum and cerebellar cortex in SD rats along with aging were investigated using a metabonomic approach based on high resolution "magic angle spinning" H-1-NMR spectroscopy and partial least squares-discriminant analysis. It was found that there were increased myo-inositol and lactate, and decreased taurine in these two brain regions of old rats. The above changes may be a marker for alterations of neuronal cells, which reduce fine motor control. Besides, some of the metabolites are gender-related and region-specific. Old female rats had decreased glutamate and increased creatine in striatum, while old male rats had increased choline in striatum, and increased GABA in cerebellar cortex, respectively. However, further analyses showed that most of the metabolites in male rats were not distinctively different with those of female ones except choline, which was in a relative lower level in striatum of male rats. All this results suggest that energy metabolism is an important indication of age-related change, which is not only in male, but also in female rats |
| 收录类别 | SCI |
| 资助信息 | We acknowledge the financial supports from National Natural Science Foundation of China No: 30801207 (to Xian- rong Zhang), No: 21105115 (to Junfang Wu) and No: 21075132 (to Xu Zhang). |
| 语种 | 英语 |
| WOS记录号 | WOS:000318326100004 |
| 公开日期 | 2013-05-31 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7445]  |
| 专题 | 昆明动物研究所_认知障碍病理学 |
| 作者单位 | 1.Department of Physiology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China 2.Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Centre for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China 3.State Key Laboratory of Brain and Cognitive Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Zhang XR[*],Wu JF,Liu HL,et al. Age- and gender-related metabonomic alterations in striatum and cerebellar cortex in rats[J]. BRAIN RESEARCH,2013,1507(X):28-34. |
| APA | Zhang XR[*],Wu JF,Liu HL,&Zhang X.(2013).Age- and gender-related metabonomic alterations in striatum and cerebellar cortex in rats.BRAIN RESEARCH,1507(X),28-34. |
| MLA | Zhang XR[*],et al."Age- and gender-related metabonomic alterations in striatum and cerebellar cortex in rats".BRAIN RESEARCH 1507.X(2013):28-34. |
入库方式： OAI收割
来源：昆明动物研究所
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