Functional Degradation of the Primary Visual Cortex During Early Senescence in Rhesus Monkeys
文献类型：期刊论文
| 作者 | Fu Y1,2; Yu S3,5; Ma YY2; Wang YC3,4; Zhou YF[*]3 |
| 刊名 | CEREBRAL CORTEX
 |
| 出版日期 | 2013 |
| 卷号 | 23期号:12页码:2923-2931 |
| 关键词 | direction selectivity dynamic range early aging orientation selectivity V1 |
| 通讯作者 | zhouy@ustc.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | Visual function in humans degrades during the early stage of senescence beginning from middle 50s to 60s. To identify its underlying neural mechanisms, we investigated the aging effects on the primary visual cortex (V1) cells in early senescent (ES) monkeys (Macaca mulatta). Under anesthesia, receptive field properties of V1 cells were examined by extracellular single-unit recordings in the young adult (YA; 56 years old), ES (1924 years old), and late senescent (LS; 2832 years old) monkeys. We found clear indications of functional degradation in early senescence, including impaired stimulus selectivities, increased level of spontaneous activity and declined signal-to-noise ratio, and dynamic range of V1 cell responses. Importantly, the functional degradation in early senescence exhibited unique features that were different from the results for the LS animals, such as remarkable individual variability in orientation selectivity and unchanged peak response elicited by visual stimulation. Our results demonstrate that the function of V1 degrades during the early stage of aging in nonhuman primate, suggesting potential neural correlates for functional deficits observed in early senescence in human subjects. Moreover, these results provide new insight into the dynamics of the aging-related functional deterioration, revealing a more complex and heterogeneous picture of this process. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Basic Research Program of China (973 Programs, 2011CBA00405, 2011CB707800, and 2009CB941303), National Natural Science Foundation of China (31230032 and 30970978 to Y.Z.), Main Direction Program of Knowledge Innovation of Chinese Academy of Sciences (KSCX2-EW-J-23), the Training Program for Young Backbone Teachers of Yunnan University, the research foundation of Yunnan University (2011YB22), Natural Science Foundation of Yunnan Province (2011FZ012), and the special fund of the “211” third phase project of Yunnan University (21134018). |
| 语种 | 英语 |
| WOS记录号 | WOS:000327431400013 |
| 公开日期 | 2013-12-20 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7741]  |
| 专题 | 昆明动物研究所_认知障碍病理学 |
| 作者单位 | 1.Biomedical Engineering laboratory, Information School, Yunnan University, Kunming, Yunnan 650091, PR China 2.State Key Laboratory of Brain and Cognitive Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, PR China 3.Department of Neurobiology and Biophysics, School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, PR China 4.Evergreen Biotech, Inc. Shangyu, Zhejiang 312300, PR China 5.Current address: Section on Critical Brain Dynamics, National Institute of Mental Health, Bethesda, MD 20892, USA |
| 推荐引用方式 GB/T 7714 | Fu Y,Yu S,Ma YY,et al. Functional Degradation of the Primary Visual Cortex During Early Senescence in Rhesus Monkeys[J]. CEREBRAL CORTEX,2013,23(12):2923-2931. |
| APA | Fu Y,Yu S,Ma YY,Wang YC,&Zhou YF[*].(2013).Functional Degradation of the Primary Visual Cortex During Early Senescence in Rhesus Monkeys.CEREBRAL CORTEX,23(12),2923-2931. |
| MLA | Fu Y,et al."Functional Degradation of the Primary Visual Cortex During Early Senescence in Rhesus Monkeys".CEREBRAL CORTEX 23.12(2013):2923-2931. |
入库方式： OAI收割
来源：昆明动物研究所
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