Prefrontal dysfunction and a monkey model of schizophrenia
文献类型：期刊论文
| 作者 | Mao P2; Cui D3; Zhao XD3; Ma YY[*]1,3,4 |
| 刊名 | NEUROSCIENCE BULLETIN
 |
| 出版日期 | 2015 |
| 卷号 | 31期号:2页码:235-241 特刊: SI |
| 关键词 | prefrontal cortex schizophrenia monkey model |
| 通讯作者 | yuanma0716@vip.sina.com |
| 合作状况 | 其它 |
| 英文摘要 | The prefrontal cortex is implicated in cognitive functioning and schizophrenia. Prefrontal dysfunction is closely associated with the symptoms of schizophrenia. In addition to the features typical of schizophrenia, patients also present with aspects of cognitive disorders. Based on these relationships, a monkey model mimicking the cognitive symptoms of schizophrenia has been made using treatment with the non-specific competitive N-methyl-D-aspartate receptor antagonist, phencyclidine. The symptoms are ameliorated by atypical antipsychotic drugs such as clozapine. The beneficial effects of clozapine on behavioral impairment might be a specific indicator of schizophrenia-related cognitive impairment. |
| 资助信息 | This review was supported by National Basic Research Development Program (973 program) of China (2012CB825500, 2011CB707800), National Natural Science Foundation of China (31271168, 91132307/H09, 61178051) and Finnish-Chinese Joint Project of National Natural Science Foundation of China (813111172). |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000352152800010 |
| 公开日期 | 2015-05-08 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8318]  |
| 专题 | 昆明动物研究所_认知障碍病理学 |
| 作者单位 | 1.Yunnan Key Laboratory of Primate Biomedical Research, Kunming 650500, China 2.Kunming General Hospital of Chengdu Military Command, Kunming 650032, China 3.State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China 4.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Mao P,Cui D,Zhao XD,et al. Prefrontal dysfunction and a monkey model of schizophrenia[J]. NEUROSCIENCE BULLETIN,2015,31(2):235-241 特刊: SI. |
| APA | Mao P,Cui D,Zhao XD,&Ma YY[*].(2015).Prefrontal dysfunction and a monkey model of schizophrenia.NEUROSCIENCE BULLETIN,31(2),235-241 特刊: SI. |
| MLA | Mao P,et al."Prefrontal dysfunction and a monkey model of schizophrenia".NEUROSCIENCE BULLETIN 31.2(2015):235-241 特刊: SI. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。