An odor detection system based on automatically trained mice by relative go no-go olfactory operant conditioning
文献类型：期刊论文
| 作者 | He J1; Wei JK1,2; Rizak JD1,2; Chen YM3; Wang JH1; Hu XT[*]1,4,5; Ma YY[*]1,4,5 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:X页码:e10019 |
| 通讯作者 | xthu@mail.kiz.ac.cn ; yuanma0716@vip.sina.com |
| 合作状况 | 其它 |
| 英文摘要 | Odor detection applications are needed by human societies in various circumstances. Rodent offers unique advantages in developing biologic odor detection systems. This report outlines a novel apparatus designed to train maximum 5 mice automatically to detect odors using a new olfactory, relative go no-go, operant conditioning paradigm. The new paradigm offers the chance to measure real-time reliability of individual animal's detection behavior with changing responses. All of 15 water-deprivation mice were able to learn to respond to unpredictable delivering of the target odor with higher touch frequencies via a touch sensor. The mice were continually trained with decreasing concentrations of the target odor (n-butanol), the average correct percent significantly dropped when training at 0.01% solution concentration; the alarm algorithm showed excellent recognition of odor detection behavior of qualified mice group through training. Then, the alarm algorithm was repeatedly tested against simulated scenario for 4 blocks. The mice acted comparable to the training period during the tests, and provided total of 58 warnings for the target odor out of 59 random deliveries and 0 false alarm. The results suggest this odor detection method is promising for further development in respect to various types of odor detection applications. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by National Basic Research Program of China (2012CB825500, 2011CB707800), National Natural Science Foundation of China (91132307/H09, 31271167, 31271168), NSFC Chinese-Finnish joint project (813111172), and Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120). |
| 语种 | 英语 |
| 公开日期 | 2015-06-08 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8334]  |
| 专题 | 昆明动物研究所_认知障碍病理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_神经系统编码 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.University of the Chinese Academy of Sciences, Beijing 100049, China 3.Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan 650550, China 4.State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China 5.Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China |
| 推荐引用方式 GB/T 7714 | He J,Wei JK,Rizak JD,et al. An odor detection system based on automatically trained mice by relative go no-go olfactory operant conditioning[J]. SCIENTIFIC REPORTS,2015,5(X):e10019. |
| APA | He J.,Wei JK.,Rizak JD.,Chen YM.,Wang JH.,...&Ma YY[*].(2015).An odor detection system based on automatically trained mice by relative go no-go olfactory operant conditioning.SCIENTIFIC REPORTS,5(X),e10019. |
| MLA | He J,et al."An odor detection system based on automatically trained mice by relative go no-go olfactory operant conditioning".SCIENTIFIC REPORTS 5.X(2015):e10019. |
入库方式： OAI收割
来源：昆明动物研究所
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