A natural model of behavioral depression in postpartum adult female cynomolgus monkeys (Macaca fascicularis)
文献类型：期刊论文
| 作者 | Chu XX1,3; Rizak JD1,3; Hu XT[*]1,2; Yang SC1; Wang JH1,2; Ma YY[*]1,2 |
| 刊名 | Zoological Research
 |
| 出版日期 | 2014 |
| 卷号 | 35期号:3页码:174-181 |
| 关键词 | Postpartum depression Cynomolgus monkeys Huddle behavior Locomotion activity Stressful events Hair cortisol Maternal relationship |
| 通讯作者 | yuanma0716@vip.sina.com ; xthu@ mail. kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Postpartum depression (PPD) is a modified form of major depressive disorders (MDD) that can exert profound negative effects on both mothers and infants than MDD. Within the postpartum period, both mothers and infants are susceptible; but because PPD typically occurs for short durations and has moderate symptoms, there exists challenges in exploring and addressing the underlying cause of the depression. This fact highlights the need for relevant animal models. In the present study, postpartum adult female cynomolgus monkeys (Macaca fascicularis) living in breeding groups were observed for typical depressive behavior. The huddle posture behavior was utilized as an indicator of behavioral depression postpartum (BDP) as it has been established as the core depressive-like behavior in primates. Monkeys were divided into two groups: A BDP group (n=6), which were found to spend more time huddling over the first two weeks postpartum than other individuals that formed a non-depression control group (n=4). The two groups were then further analyzed for locomotive activity, stressful events, hair cortisol levels and for maternal interactive behaviors. No differences were found between the BDP and control groups in locomotive activity, in the frequencies of stressful events experienced and in hair cortisol levels. These findings suggested that the postpartum depression witnessed in the monkeys was not related to external factors other than puerperium period. Interestingly, the BDP monkeys displayed an abnormal maternal relationship consisting of increased infant grooming. Taken together, these findings suggest that the adult female cynomolgus monkeys provide a natural model of behavioral postpartum depression that holds a number of advantages over commonly used rodent systems in PPD modeling. The cynomolgus monkeys have a highly-organized social hierarchy and reproductive characteristics without seasonal restriction—similar to humans—as well as much greater homology to humans than rodents. As such, this model may provide a greater translational efficiency and research platform for systematically investigating the etiology, treatment, prevention of PPD. |
| 收录类别 | 其他 |
| 资助信息 | This study was supported by National Natural Science Foundation of China (31271167, 81271495, 31070963, 30921064), the Yunnan Provincial Project to attract ore-hundred exceptional talents from Overseas. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9289]  |
| 专题 | 昆明动物研究所_认知障碍病理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_神经系统编码 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.Laboratory of Primate Neuroscience Research and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, China 2.Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 3.University of the Chinese Academy of Sciences, Beijing 100049, China |
| 推荐引用方式 GB/T 7714 | Chu XX,Rizak JD,Hu XT[*],et al. A natural model of behavioral depression in postpartum adult female cynomolgus monkeys (Macaca fascicularis)[J]. Zoological Research,2014,35(3):174-181. |
| APA | Chu XX,Rizak JD,Hu XT[*],Yang SC,Wang JH,&Ma YY[*].(2014).A natural model of behavioral depression in postpartum adult female cynomolgus monkeys (Macaca fascicularis).Zoological Research,35(3),174-181. |
| MLA | Chu XX,et al."A natural model of behavioral depression in postpartum adult female cynomolgus monkeys (Macaca fascicularis)".Zoological Research 35.3(2014):174-181. |
入库方式： OAI收割
来源：昆明动物研究所
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