Interactive effects of morphine and scopolamine, MK-801, propanolol on spatial working memory in rhesus monkeys
文献类型：期刊论文
| 作者 | Wang JH[*]1; Chen YM1; Ma YY1; Carlson S2; Li L3; Hu XT1 |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2012 |
| 卷号 | 523期号:2页码:119-124 |
| 关键词 | Working memory Scopolamine Morphine MK-801 Propranolol Rhesus monkeys |
| 通讯作者 | wjh16@hotmail.com |
| 合作状况 | 其它 |
| 英文摘要 | Opiate, cholinergic, glutamatergic and beta-adrenergic neurotransmitters play key roles in learning and memory in humans and animals. Dysfunction of the interactions between these neurotransmitters may induce human diseases. In the present study, the interactions of morphine and acetylcholine (ACh). NMDA, and beta-adrenergic receptor antagonist (scopolamine, MK-801, and propanolol) were evaluated in a single-blind design by co-administrations of morphine and these drugs in a delayed response in rhesus monkeys. The results indicated that: (1) Co-administration of morphine and scopolamine deteriorated spatial working memory. (2) Co-treatment of morphine and MK-801 restored impairment caused by morphine and MK-801 in a dose-depending pattern. (3) Morphine plus propranolol impaired spatial working memory. High dose of morphine (0.01 mg/kg) reversed impaired spatial working memory induced by single propranolol and morphine treatment. These data suggested that the interactions of morphine and AChergic, NMDAergic and beta-adrenergic compounds were involved in spatial working memory in rhesus monkeys. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by 973 program (2011CB707800), NSFC (31070963 and 31070965), and KSCX2-EW- J-23. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9576]  |
| 专题 | 昆明动物研究所_认知障碍病理学 昆明动物研究所_神经系统编码 |
| 作者单位 | 1.Laboratory of Primate Neurosciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, PR China 2.Neuroscience Unit, Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland 3.Department of Psychology, Peking University, Beijing 100871, PR China |
| 推荐引用方式 GB/T 7714 | Wang JH[*],Chen YM,Ma YY,et al. Interactive effects of morphine and scopolamine, MK-801, propanolol on spatial working memory in rhesus monkeys[J]. NEUROSCIENCE LETTERS,2012,523(2):119-124. |
| APA | Wang JH[*],Chen YM,Ma YY,Carlson S,Li L,&Hu XT.(2012).Interactive effects of morphine and scopolamine, MK-801, propanolol on spatial working memory in rhesus monkeys.NEUROSCIENCE LETTERS,523(2),119-124. |
| MLA | Wang JH[*],et al."Interactive effects of morphine and scopolamine, MK-801, propanolol on spatial working memory in rhesus monkeys".NEUROSCIENCE LETTERS 523.2(2012):119-124. |
入库方式： OAI收割
来源：昆明动物研究所
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