Early Adversity Contributes to Chronic Stress Induced Depression-like Behavior in Adolescent Male Rhesus Monkeys
文献类型：期刊论文
| 作者 | Zhang ZY1,2; Mao Y1,3,4; Ma YY1; Qin DD[*]1; Hu XT[*]1,5; Feng XL1; Zheng N1,2; Lv LB4 |
| 刊名 | BEHAVIOURAL BRAIN RESEARCH
 |
| 出版日期 | 2016 |
| 卷号 | 306期号:X页码:154-159 |
| 关键词 | Early adversity Chronic unpredictable stress Cortisol Depression Monkeys |
| 通讯作者 | gindong108@163.com |
| 合作状况 | 其它 |
| 英文摘要 | Chronic stress is an important cause for depression. However, not everyone who is exposed to chronic stress will develop depression. Our previous studies demonstrated that early adversity can cause lasting changes in adolescent rhesus monkeys, but depressive symptoms have not been observed. Compared to adults, it is still unknown that whether adolescent rhesus monkeys experiencing early adversity are more likely to develop depressive symptoms. In this study, we investigated the long term relationship between early adversity, chronic stress and adolescent depression for the first time. Eight male rhesus monkeys were reared in maternal separation (MS) or mother-reared (MR) conditions. All of them went through unpredictable chronic stress for two months at their age four. The stressors included space restriction, intimidation, long illumination and fasting. Behavioral and physiological data were collected during the experiment. The results showed that, compared with the MR group, the locomotor activity of MS group was significantly decreased after one month of chronic stress while huddling up and stereotypical behaviors were significantly increased. Moreover, this trend continued and even worsened at the second month. Significantly higher hair cortisol levels and lower body weight were observed in MS group after two months of stress. These results indicate that early adversity is one of the environmental factors which can increase the susceptibility of depression when experiencing chronic stress in the later life. This will further clarify the important roles of early environmental factors in the development of adolescent depression and children rearing conditions should receive more attention. |
| 收录类别 | SCI |
| 资助信息 | This research was supported by the National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825500, 2012CBA01304), the Strategic Priority Research Program of CAS (XDB02020000), Selected Frontier Scientific Signif- icant Breakthrough Project of CAS, the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), the Training Program of the Major Research Plan of the National Natural Science Founda- tion of China (91332120), the National Natural Science Foundation of China (81471312, 81460352, 31271167, 81271495), The Yun- nan Provincial Project to Attract One-hundred Exceptional Talents From Overseas, the Natural Science Foundation of Yunnan Province of China (2010ZC218), and the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (2014FA047). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9646]  |
| 专题 | 昆明动物研究所_认知障碍病理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_神经系统编码 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.University of the Chinese Academy of Sciences, Beijing 100049, China 3.Center for Drug Safety Evaluation, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 4.Kunming Primate Research Center, Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 5.CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China |
| 推荐引用方式 GB/T 7714 | Zhang ZY,Mao Y,Ma YY,et al. Early Adversity Contributes to Chronic Stress Induced Depression-like Behavior in Adolescent Male Rhesus Monkeys[J]. BEHAVIOURAL BRAIN RESEARCH,2016,306(X):154-159. |
| APA | Zhang ZY.,Mao Y.,Ma YY.,Qin DD[*].,Hu XT[*].,...&Lv LB.(2016).Early Adversity Contributes to Chronic Stress Induced Depression-like Behavior in Adolescent Male Rhesus Monkeys.BEHAVIOURAL BRAIN RESEARCH,306(X),154-159. |
| MLA | Zhang ZY,et al."Early Adversity Contributes to Chronic Stress Induced Depression-like Behavior in Adolescent Male Rhesus Monkeys".BEHAVIOURAL BRAIN RESEARCH 306.X(2016):154-159. |
入库方式： OAI收割
来源：昆明动物研究所
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