Morphine-induced conditioned place preference in rhesus monkeys: resistance to inactivation of insula and extinction
文献类型：期刊论文
| 作者 | Wu XJ1,2; Zhao N3; Wei JK1,2; Zong W1; Yang LX4; Ryabinine AE5; Ma YY[*]1; Wang JH[*]1; Bai F1; Li CY1 |
| 刊名 | NEUROBIOLOGY OF LEARNING AND MEMORY
 |
| 出版日期 | 2016 |
| 卷号 | 131期号:X页码:192-200 |
| 关键词 | Conditioned place preference (CPP) Extinction Insula Morphine associated memory Rhesus monkey |
| 通讯作者 | wangjh@mail.kiz.ac.cn |
| 英文摘要 | Drug addicts experience strong craving episodes in response to drug-associated cues. Attenuating these responses using pharmacological or behavioral approaches could aid recovery from addiction. Cue-induced drug seeking can be modeled using the conditioned place preference procedure (CPP). Our previous work showed that conditioned place preference (CPP) can be induced by administration of increasing doses of morphine in rhesus monkeys. Here, we investigated whether expression of morphine-induced CPP can be attenuated by inhibiting activity of insular cortex or by repeated unreinforced exposures to the CPP test. The insula has been demonstrated to be involved in addiction to several drugs of abuse. To test its role in morphine CPP, bilateral cannulae were implanted into the insula in seven adult monkeys. The CPP was established using a biased apparatus by intramuscular injections of morphine at increasing doses (1.5, 3 and 4.5 mg/kg) for each monkey. After the monkeys established morphine CPP, their insulae were reversibly inactivated by bilateral microinjection with 5% lidocaine (40 ul) prior to the post-conditioning test (expression) of CPP using a within-subject design. The microinjections of lidocaine failed to affect CPP expression when compared to saline injections. We subsequently investigated morphine-associated memory during six episodes of CPP tests performed in these monkeys over the following 75±0.2 months. While the preference score showed a declining trend with repeated testing, morphine-induced CPP was maintained even on the last test performed at 75 months post-conditioning. This observation indicated strong resistance of morphine-induced memories to extinction in rhesus monkeys. Although these data do not confirm involvement of insula in morphine-induced CPP, our observation that drug-associated memories can be maintained over six drug-free years following initial experience with morphine has important implications for treatment of drug addiction using extinction therapy. |
| 资助信息 | This study was supported by 973 program (2012CB825500, 2011CB707800), NSFC (31271168, 91132307/H09, 31571109), NSFC Chinese-Finnish joint project 813111172 and Yunnan key program of science and technology (2014FC005). The authors declare no competing financial interests. We thank Nanhui Chen and Jing Wu for supportive interactions. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9745]  |
| 专题 | 昆明动物研究所_认知障碍病理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_神经系统编码 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China 3.Second Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, Chin 4.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 5.Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA |
| 推荐引用方式 GB/T 7714 | Wu XJ,Zhao N,Wei JK,et al. Morphine-induced conditioned place preference in rhesus monkeys: resistance to inactivation of insula and extinction[J]. NEUROBIOLOGY OF LEARNING AND MEMORY,2016,131(X):192-200. |
| APA | Wu XJ.,Zhao N.,Wei JK.,Zong W.,Yang LX.,...&Liu CR.(2016).Morphine-induced conditioned place preference in rhesus monkeys: resistance to inactivation of insula and extinction.NEUROBIOLOGY OF LEARNING AND MEMORY,131(X),192-200. |
| MLA | Wu XJ,et al."Morphine-induced conditioned place preference in rhesus monkeys: resistance to inactivation of insula and extinction".NEUROBIOLOGY OF LEARNING AND MEMORY 131.X(2016):192-200. |
入库方式： OAI收割
来源：昆明动物研究所
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