Differential effects of aging on EEG after baclofen administration
文献类型：期刊论文
| 作者 | Fu Y[*]1; Cui JH1; Ma YY2 |
| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2011 |
| 卷号 | 54期号:5页码:459-465 |
| 关键词 | aging baclofen EEG spectra power rat |
| 通讯作者 | fuyu@ynu.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | Baclofen is a selective gamma-aminobutyric acid (GABA) type B agonist that may have important medicinal uses, such as in analgesics and drug addiction treatment. In addition, evidence is accumulating that suggests GABAergic-mediated neurotransmission is altered during aging. This study investigated whether baclofen administration (5 mg kg(-1)) induces differential effects on cortical electrical activity with age. Electroencephalograms (EEGs) were recorded from young (3-4 months) and aged (15-17 months) rats, and both the absolute and relative powers in five frequency bands (delta: 2-4 Hz; theta: 4-8 Hz; alpha: 8-12 Hz; beta: 12-20 Hz; gamma: 20-100 Hz) were analyzed. Before administration of baclofen, we found that the EEG relative power in the beta band was higher in the aged than that in the young rats. After administration of baclofen, there was a slower increase in the relative power in the delta band in the aged than that in the young rats. Moreover, there was no significant difference between the two age groups in absolute power in any frequency band. These findings indicate that baclofen treatment appears to differentially modify cortical EEG activity as a function of age. Our data further elucidate the relationship between GABA(B) receptor-mediated neurotransmission and aging. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the Training Program for Young Backbone Teachers of Yunnan University, the Research Foundation of Yunnan University (Grant No. 2008YB007), the Science Foundation of the Education Department of Yunnan (Grant No. 09Y0034), the Special Fund of the “211” Third Phase Project of Yunnan University (Grant No. 21134018) and the National College Student Inno- vation Experiment Program (Grant No. 101067312). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10431]  |
| 专题 | 昆明动物研究所_认知障碍病理学 |
| 作者单位 | 1.Department of Electronic Engineering, Information School, Yunnan University, Kunming 650091, China 2.State Key Laboratory of Brain and Cognitive Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Fu Y[*],Cui JH,Ma YY. Differential effects of aging on EEG after baclofen administration[J]. SCIENCE CHINA-LIFE SCIENCES,2011,54(5):459-465. |
| APA | Fu Y[*],Cui JH,&Ma YY.(2011).Differential effects of aging on EEG after baclofen administration.SCIENCE CHINA-LIFE SCIENCES,54(5),459-465. |
| MLA | Fu Y[*],et al."Differential effects of aging on EEG after baclofen administration".SCIENCE CHINA-LIFE SCIENCES 54.5(2011):459-465. |
入库方式： OAI收割
来源：昆明动物研究所
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