Effects of morphine and its withdrawal on Y-maze spatial recognition memory in mice
文献类型：期刊论文
| 作者 | Ma MX1; Chen YM2,3; He J2,3; Zeng T2,3; Wang JH[*]2,3 |
| 刊名 | NEUROSCIENCE
 |
| 出版日期 | 2007 |
| 卷号 | 147期号:4页码:1059-1065 |
| 关键词 | morphine spatial recognition memory mice Y-maze |
| 通讯作者 | wangjh@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Effects of morphine on acquisition and retrieval of memory have been proven in the avoidance paradigms. In present study, we used a two-trial recognition Y-maze to test the effects of acute morphine and morphine withdrawal on spatial recognition memory. The Y-maze is based on the innate tendency of rodents to explore novel environments and therefore avoid punishment and reward. Results: 1) Pre-training morphine 10 mg/kg impaired the recognition spatial memory of acquisition after a 1 h inter-trial interval (ITI), whereas morphine 2.5, 5 and 10 mg/kg showed impairment after 2 h ITI. 2) Preretention morphine 5, 10 mg/kg disrupted the retrieval of memory after 1 h ITI. 3) Morphine 5 and 10 mg/kg caused hyperlocomotor activity depending on the state. 4) Mice withdrawn from morphine 40 mg/kg but not 10 mg/kg for 3 days showed amnesia in Y-maze. Our data suggested that acute morphine impaired the acquisition and retrieval of spatial recognition memory and increased the locomotor activity in the Y-maze depending on the dose and state. Moreover, withdrawal from chronic morphine also impaired acquisition in the Y-maze depending on the dose and state. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the National Science Foundation of China (NSFC 30470553 and 30530270), the Chinese Academy of Science Grants (KSCX2-SW-217-03) and 973 program (2005CB522803). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10528]  |
| 专题 | 昆明动物研究所_认知障碍病理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_神经系统编码 |
| 作者单位 | 1.Department of Psychology, Jilin University, Changchun, 130012, PR China 2.Laboratory of Primate Neuroscience Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, #32 Jiao Chang Dong Lu, Kunming, Yunnan, 650223, PR China 3.Graduate School of Chinese Academy of Sciences, #19 Yuquan Lu, Beijing, 100049, PR China |
| 推荐引用方式 GB/T 7714 | Ma MX,Chen YM,He J,et al. Effects of morphine and its withdrawal on Y-maze spatial recognition memory in mice[J]. NEUROSCIENCE,2007,147(4):1059-1065. |
| APA | Ma MX,Chen YM,He J,Zeng T,&Wang JH[*].(2007).Effects of morphine and its withdrawal on Y-maze spatial recognition memory in mice.NEUROSCIENCE,147(4),1059-1065. |
| MLA | Ma MX,et al."Effects of morphine and its withdrawal on Y-maze spatial recognition memory in mice".NEUROSCIENCE 147.4(2007):1059-1065. |
入库方式： OAI收割
来源：昆明动物研究所
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