Age-related effects of bromocriptine on sensory gating in rhesus monkeys
文献类型：期刊论文
| 作者 | Liu N1,3,4; Yu S2; Zhou YF2; Cai JX1,2; Ma YY[*]1,3 |
| 刊名 | NEUROREPORT
 |
| 出版日期 | 2005 |
| 卷号 | 16期号:6页码:603-606 |
| 关键词 | aging dopamine rhesus monkeys sensory gating |
| 通讯作者 | yuanma@hotmail.com |
| 英文摘要 | Declines in dopamine neurotransmission are a robust characteristic of the process of normal aging. Using neuroimaging, biochemical and cognitive methods, age-related reduction of D2 receptor has been noted in a wide range of species. On the other hand, it is well known that dopamine plays a crucial role in the modulation of sensory gating. Here, we examined age-related alterations of D2 receptor in rhesus monkeys, using a sensory gating paradigm. The direct D2 receptor agonist, bromocriptine, was characterized in young adult and aged monkeys.We found bromocriptine disrupted sensory gating in young adult monkeys but not in aged ones. Our results provided new evidence that there is a functional decline of D2 receptor in aged monkeys.© 2005 Lippincott Williams & Wilkins. |
| 收录类别 | SCI |
| 资助信息 | Thiswork was supportedby the ChineseAcademyofScience Grants(KSCX2-SW for M.Y .),National Basic ResearchProgramofChina,ChineseNationalScienceFoundation(30470553),ProgramofChineseAcademyofScience(KJCX1-01), National Natural Science Foundation of China (Major International JointResearch Program,YZ),Foundation of ChineseAcademy of Sciences(KSCX2-SW-217-03) and National Institute ofAging (NIH)grant AG-17922.Wegratefullyacknowledge the expert technicalassistanceby S.H.Tian,Y .D.Fanand Y .C.Liu. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10891]  |
| 专题 | 昆明动物研究所_认知障碍病理学 昆明动物研究所_其他 |
| 作者单位 | 1.Kunming Institute of Zoology,Chinese Academyof Sciences,Kunming 650223,PRChina 2.Schoolof Life Sciences, UniversityofScience & TechnologyofChina,Hefei 230027 ,PRChina 3.Centerof Brain and Mind,Chinese Academyof Sciences, Beijing100080,PRChin 4.The Graduate Schoolof the Chinese Academyof Science, Beijing100039,PRChina |
| 推荐引用方式 GB/T 7714 | Liu N,Yu S,Zhou YF,et al. Age-related effects of bromocriptine on sensory gating in rhesus monkeys[J]. NEUROREPORT,2005,16(6):603-606. |
| APA | Liu N,Yu S,Zhou YF,Cai JX,&Ma YY[*].(2005).Age-related effects of bromocriptine on sensory gating in rhesus monkeys.NEUROREPORT,16(6),603-606. |
| MLA | Liu N,et al."Age-related effects of bromocriptine on sensory gating in rhesus monkeys".NEUROREPORT 16.6(2005):603-606. |
入库方式： OAI收割
来源：昆明动物研究所
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