基于Labview 的清醒猕猴眼动行为控制脑机理研究系统的设计与实现
文献类型：学位论文
| 作者 | 张玉华 |
| 学位类别 | 硕士 |
| 答辩日期 | 2013-11 |
| 授予单位 | 中国科学院研究生院 |
| 授予地点 | 北京 |
| 导师 | 马原野 |
| 关键词 | 眼动行为控制 神经元放电 电刺激伪迹消除 虚拟仪器 Labview |
| 其他题名 | A Labview-Based Research System for the study of the Eye Movement and Its Brain Mechanisms in awake monkeys |
| 学位专业 | 生物工程 |
| 中文摘要 | 猕猴由于其进化和脑结构上与人类近似等原因，在脑功能研究中成为了人类的“替身”和“活的精密仪器”。脑功能研究的核心是脑与行为之间的关系，也就是各种行为产生的脑机理。眼睛运动是纷繁复杂的行为中最容易实现精确测量的一种简单运动，且目前眼动控制系统的基本神经回路已经清楚，是神经回路研究中研究最为深入的运动控制系统。因此清醒猕猴的眼动控制系统作为一个不可多得的运动控制模型，对脑机理的研究具有重要的意义。 “偷听”和“模仿”是脑机理研究中神经回路研究的重要手段，“偷听”是基于行为控制来记录相关的神经元放电，“模仿”则是用电刺激来兴奋相关回路中的不同脑区和核团，产生特定的行为。将“模仿”和“偷听”技术结合起来，即在回路中的上游脑区或核团进行电刺激，同时在其下游核团进行记录，来研究相关回路中上下游核团间信息如何传递，能更好地为研究神经元之间信息的编码和传递提供实验依据。然而常用的mV级别的电刺激会对幅度为μV级别的神经元放电产生巨大的电磁干扰，这使得在电刺激的同时观察神经元活动变得极其困难，目前国内外也没有很有效的解决手段。 本文的主要工作是基于一种新兴的图形化语言Labview建立一套清醒猕猴眼动行为控制脑机理研究系统。其中为了克服电刺激的同时观察神经元放电存在的困难而研制的数字化电刺激伪迹消除系统，在本领域中属于国际领先水平，已经在申请专利。 本系统主要由四个子系统组成：眼动行为控制系统、记录系统、电刺激系统和数字化电刺激伪迹消除系统组成，同时用Labview编写了对硬件的控制程序及对电刺激、眼动、电生理信号的联合分析软件。此系统是本领域中首次采用虚拟仪器的概念来设计的，大量实验结果验证了整个系统的灵活性和稳定性。 |
| 英文摘要 | Due to the similarity to human in brain structures and functions, monkeys play an important role in the study of human brain mechanism, especially about the relationship between brain and behaviors. Eye movement is the simplest movement that can be accurately measured and its basic neural control circuit is well studied. Therefore, as excellent model of brain movement control mechanisms, the eye movement control system (especially in awake monkeys) plays an important role in the study of the neural basis of brain movement control. "Monitoring" and "Imitation" are two important ways to understand the neural circuits of the brain. "Monitoring" means to record the neuronal activities with microelectrode, and "Imitation" means to use the electrical stimulation to excite related neurons in different brain regions and nuclei. If we can use both technologies at the same time, such as to record the downstream region of the brain while stimulating the upstream region, it will be easier to understand how these regions work together. However, the stimulation will cause a huge artifact to the neuronal activities through electromagnetic interference when the electrical stimulation take actions, and it will make the observation of the neuronal activity became extremely difficult. Up till now, there is no effective method to solve this problem. The main contribution of this study is to develop a Labview-based research system for the study of the eye movement and its brain mechanisms on the awake monkeys. The most important part of this system is Electronic stimulus artifact elimination system, which is built to overcome the difficulties of observing the neuronal activities while electric stimulating. This technique is under the process of applying for a patent. The whole system consists of four main parts: Eye movement control system, Recording system, Electrical stimulation system and Electrical stimulation artifact elimination system. Labview was used to control the hardware and analyze all the data. A lot of experiments had been carried out using this system and a large number of experimental results had already verified the system's stability and flexibility. |
| 语种 | 中文 |
| 公开日期 | 2013-12-25 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7748]  |
| 专题 | 昆明动物研究所_认知障碍病理学 |
| 推荐引用方式 GB/T 7714 | 张玉华. 基于Labview 的清醒猕猴眼动行为控制脑机理研究系统的设计与实现[D]. 北京. 中国科学院研究生院. 2013. |
入库方式： OAI收割
来源：昆明动物研究所
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