Propofol facilitates the development of long-term depression (LTD) and impairs the maintenance of long-term potentiation (LTP) in the CA1 region of the hippocampus of anesthetized rats
文献类型：期刊论文
| 作者 | Wei HM1,2; Xiong WY3; Yang SC3; Zhou QX3; Liang CL2; Zeng BX1; Xu L[*]3 |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2002 |
| 卷号 | 324期号:3页码:181-184 |
| ISSN号 | 0304-3940 |
| 关键词 | long-term potentiation long-term depression memory anesthetics propofol hippocampus Wistar rat |
| 通讯作者 | lxu@vip.163.com |
| 合作状况 | 其它 |
| 英文摘要 | Memory is sensitive to the short-acting anesthetic (2,6-diisopropylphenol) propofol, but the underlying mechanism is little known. Here, we have examined the effects of propofol on synaptic plasticity in the CA1 region of the hippocampus of anesthetized rats. We found that low dose of propofol (20 mg/kg, i.p.) did not affect the basal transmission, but enhanced prominently the development of long-term depression (LTD) and impaired the maintenance of long-term potentiation (LTP). The impairment of LTP maintenance and enhancement of LTD development may contribute to propofol-induced deficits in memory following propofol anesthesia. |
| 资助信息 | National Basic Research Program G1999054000, National Natural Science grants 39870280, 39925011, 39930080 and Yunnan Science Foundation grant 98C111M of China to LX supported this work. |
| 收录类别 | SCI |
| 原文出处 | 2002324181.pdf |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5843]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_神经系统编码 |
| 作者单位 | 1.Anesthesiological Section, Union Hospital affiliated to TongJi Medical College, Huazhong University of Technology, WuHan, PR China 2.Kunming General Hospital, ChengDu Military area, Kunming 650223, PR China 3.Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Science, Yunnan, Kunming 650223, PR China |
| 推荐引用方式 GB/T 7714 | Wei HM,Xiong WY,Yang SC,et al. Propofol facilitates the development of long-term depression (LTD) and impairs the maintenance of long-term potentiation (LTP) in the CA1 region of the hippocampus of anesthetized rats[J]. NEUROSCIENCE LETTERS,2002,324(3):181-184. |
| APA | Wei HM.,Xiong WY.,Yang SC.,Zhou QX.,Liang CL.,...&Xu L[*].(2002).Propofol facilitates the development of long-term depression (LTD) and impairs the maintenance of long-term potentiation (LTP) in the CA1 region of the hippocampus of anesthetized rats.NEUROSCIENCE LETTERS,324(3),181-184. |
| MLA | Wei HM,et al."Propofol facilitates the development of long-term depression (LTD) and impairs the maintenance of long-term potentiation (LTP) in the CA1 region of the hippocampus of anesthetized rats".NEUROSCIENCE LETTERS 324.3(2002):181-184. |
入库方式： OAI收割
来源：昆明动物研究所
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