How does the motor relearning program improve neurological function of brain ischemia monkeys?**
文献类型：期刊论文
| 作者 | Yin Y1; Gu Z2; Pan L1; Gan L1; Qin DD3; Yang B4; Guo J5; Hu XT3; Wang TH6; Feng ZT[*]6 |
| 刊名 | NEURAL REGENERATION RESEARCH
 |
| 出版日期 | 2013 |
| 卷号 | 8期号:16页码:1445-1454 |
| 关键词 | neural regeneration brain injury stroke grants-supported paper neuroregeneration motor relearning program rhesus macaque brain ischemia animal model neurological function neurotrophic factor single-photon emission CT cerebral blood flow |
| 通讯作者 | zhongtangfeng@sina.com |
| 合作状况 | 其它 |
| 英文摘要 | The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues, glial fibrillary acidic protein and neurofilament protein changes can reflect the condition of injured neurons and astrocytes, while vascular endothelial growth factor and basic fibroblast growth factor changes can indicate angiogenesis. In the present study, we induced ischemic brain injury in the rhesus macaque by electrocoagulation of the M1 segment of the right middle cerebral artery. The motor relearning program was conducted for 60 days from the third day after model establishment. Immunohistochemistry and single-photon emission CT showed that the numbers of glial fibrillary acidic protein-, neurofilament protein-, vascular endothelial growth factor- and basic fibroblast growth factor-positive cells were significantly increased in the infarcted side compared with the contralateral hemisphere following the motor relearning program. Moreover, cerebral blood flow in the infarcted side was significantly improved. The clinical rating scale for stroke was used to assess neurological function changes in the rhesus macaque following the motor relearning program. Results showed that motor function was improved, and problems with consciousness, self-care ability and balance function were significantly ameliorated. These findings indicate that the motor relearning program significantly promoted neuronal regeneration, repair and angiogenesis in the surroundings of the infarcted hemisphere, and improve neurological function in the rhesus macaque following brain ischemia. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the Combined Specific Foundation of Department of Science and Technology of Yunnan Province and Kunming Medical University, No. 2008CD037. |
| 语种 | 英语 |
| 公开日期 | 2013-07-18 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7575]  |
| 专题 | 昆明动物研究所_神经系统编码 |
| 作者单位 | 1.Department of Rehabilitation Medicine, Fourth Hospital of Kunming Medical University, Kunming 650021, Yunnan Province, China 2.Department of Neurosurgery, Fourth Hospital of Kunming Medical University, Kunming 650021, Yunnan Province, China 3.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan Province, China 4.Department of Nuclear Medicine, Fourth Hospital of Kunming Medical University, Kunming 650021, Yunnan Province, China 5.Department of Pathology, Fourth Hospital of Kunming Medical University, Kunming 650021, Yunnan Province, China 6.Institute of Neuroscience, Kunming Medical University, Kunming 650500, Yunnan Province, China |
| 推荐引用方式 GB/T 7714 | Yin Y,Gu Z,Pan L,et al. How does the motor relearning program improve neurological function of brain ischemia monkeys?**[J]. NEURAL REGENERATION RESEARCH,2013,8(16):1445-1454. |
| APA | Yin Y.,Gu Z.,Pan L.,Gan L.,Qin DD.,...&Feng ZT[*].(2013).How does the motor relearning program improve neurological function of brain ischemia monkeys?**.NEURAL REGENERATION RESEARCH,8(16),1445-1454. |
| MLA | Yin Y,et al."How does the motor relearning program improve neurological function of brain ischemia monkeys?**".NEURAL REGENERATION RESEARCH 8.16(2013):1445-1454. |
入库方式： OAI收割
来源：昆明动物研究所
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