Aging affects the direction selectivity of MT cells in rhesus monkeys
文献类型：期刊论文
| 作者 | Liang Z1; Yang Y1; Li GX1; Zhang J4; Wang YC1,2; Zhou YF[*]1,3; Leventhal AG1,2 |
| 刊名 | NEUROBIOLOGY OF AGING
 |
| 出版日期 | 2010 |
| 卷号 | 31期号:5页码:863-873 |
| 关键词 | Aging Area MT Degradation Direction selectivity Monkey Pattern cell |
| 通讯作者 | zhouy@ustc.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | The ability to accurately perceive the direction and speed of moving objects declines during normal aging. This is likely due to functional degradation of cortical neurons. Most neurons in the primate middle temporal area (MT) are direction-selective and their activity is closely linked to the perception of coherent motion. We investigated the mechanisms that underlie this age-related decline by comparing the proportions of direction-selective MT cells in old and young macaque monkeys, using in vivo single-cell recording techniques. Our results showed that the proportion of such cells was lower in old than in young monkeys. Moreover, one type of direction-sensitive cells, pattern cells, was especially sensitive to aging and was affected more severely than another class, component cells. We also found that direction selectivity was affected more severely in MT than in VI of senescent monkeys. Thus, the functional degradation of MT and VI cells may mediate perceptual decline in visual motion tasks in old primates |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the Natural Sci- ence Foundation of China (30520120072, Y.Z.), NIH/NIA R01 AG 17922 (A.G.L.) and National Basic Research Pro- gram (2006CB500804 and 2005CB522803). |
| 语种 | 英语 |
| 公开日期 | 2013-09-26 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7684]  |
| 专题 | 昆明动物研究所_神经系统编码 |
| 作者单位 | 1.Vision Research Laboratory, School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, PR China 2.Department of Neurobiology and Anatomy, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA 3.State key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, PR China 4.Laboratory of Primate Cognitive Neuroscience, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, Yunnan 650223, China |
| 推荐引用方式 GB/T 7714 | Liang Z,Yang Y,Li GX,et al. Aging affects the direction selectivity of MT cells in rhesus monkeys[J]. NEUROBIOLOGY OF AGING,2010,31(5):863-873. |
| APA | Liang Z.,Yang Y.,Li GX.,Zhang J.,Wang YC.,...&Leventhal AG.(2010).Aging affects the direction selectivity of MT cells in rhesus monkeys.NEUROBIOLOGY OF AGING,31(5),863-873. |
| MLA | Liang Z,et al."Aging affects the direction selectivity of MT cells in rhesus monkeys".NEUROBIOLOGY OF AGING 31.5(2010):863-873. |
入库方式： OAI收割
来源：昆明动物研究所
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