Cortisol responses to chronic stress in adult macaques: Moderation by a polymorphism in the serotonin transporter gene
文献类型：期刊论文
| 作者 | Qin DD[*]1,4; Rizak J1,3; Feng XL1; Yang SC1; Hu XT[*]1,2; Yang LC5; Fan XN1; Lu LB2; Chen L4 |
| 刊名 | BEHAVIOURAL BRAIN RESEARCH
 |
| 出版日期 | 2015 |
| 卷号 | 278期号:X页码:280-285 |
| 关键词 | Rhesus macaque Adult Female Rh5-HTTLPR Chronic stress Cortisol |
| 通讯作者 | qindong108@163.com ; xthu@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Accumulating evidence has shown that a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) moderates the association between stress and depressive symptoms. However, the exact etiologies underlying this moderation are not well understood. Here it is reported that among adult female rhesus macaques, an orthologous polymorphism (rh5-HTTLPR) exerted an influence on cortisol responses to chronic stress. It was found that females with two copies of the short allele were associated with increased cortisol responses to chronic stress in comparison to their counterparts who have one or two copies of the long allele. In the absence of stress, no differences related to genotype were observed in these females. This genetic moderation was found without a genetic influence on exposure to stressful situations. Rather it was found to be a genetic modulation of cortisol responses to chronic stress. These findings indicate that the rh5-HTTLPR polymorphism is closely related to hypothalamus pituitary adrenal (HPA) axis reactivity, which may increase susceptibility to depression in females with low serotonin transporter efficiency and a history of stress. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, 2012CBA01304), Strategic Priority Research Program of CAS (XDB02020000), Key Program of the Chinese Academy of Sci- ences (KZCC-EW-103-2), Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), National Natural Science Foundation of China (81471312, 31271167, 81271495), The Yunnan Provincial Project to attract one-hundred exceptional talents from Overseas, National High-tech R&D Program of China (863 Program 2012AA020701). |
| 语种 | 英语 |
| 公开日期 | 2015-02-06 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8254]  |
| 专题 | 昆明动物研究所_神经系统编码 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 2.Kunming Primate Research Center of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 3.University of the Chinese Academy of Sciences, Beijing 100049, China 4.State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China 5.School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Qin DD[*],Rizak J,Feng XL,et al. Cortisol responses to chronic stress in adult macaques: Moderation by a polymorphism in the serotonin transporter gene[J]. BEHAVIOURAL BRAIN RESEARCH,2015,278(X):280-285. |
| APA | Qin DD[*].,Rizak J.,Feng XL.,Yang SC.,Hu XT[*].,...&Chen L.(2015).Cortisol responses to chronic stress in adult macaques: Moderation by a polymorphism in the serotonin transporter gene.BEHAVIOURAL BRAIN RESEARCH,278(X),280-285. |
| MLA | Qin DD[*],et al."Cortisol responses to chronic stress in adult macaques: Moderation by a polymorphism in the serotonin transporter gene".BEHAVIOURAL BRAIN RESEARCH 278.X(2015):280-285. |
入库方式： OAI收割
来源：昆明动物研究所
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