Drift in centrality of different brain regions in an anatomical neural network with Parkinson's disease: A view from complex network analysis
文献类型：期刊论文
| 作者 | Lei X1; Huang B[2,3; Li H2,3; Jiang H4; Hu X[*]2,5; Zhang B[*]1 |
| 刊名 | NEUROSCIENCE
 |
| 出版日期 | 2015 |
| 卷号 | 299期号:X页码:107-124 |
| 关键词 | network analysis centrality anatomical connectivity network Parkinson's disease |
| 通讯作者 | xthu@mail.kiz.ac.cn ; brzhang@zju.edu.cn |
| 合作状况 | 其它 |
| 英文摘要 | Understanding the role of brain regions in anatomical neural networks with Parkinson's disease (PD) is essential for improving the clinical protocol or finding new targets for deep brain stimulation (DBS). Although numerous changes have been reported in local functional studies, few studies have reported on the anatomical network of the entire brain. Here, by developing a series of algorithms, this study provided a whole anatomical neural network of the macaque monkey. Then, the drifts in centrality from normal to PD networks were described in terms of complex network analysis and summarized with principal component analysis. Results revealed that the areas including the striatum, globus pallidus, amygdala, prefrontal lobe, thalamus, hippocampus, visual cortex, insula, etc., showed relatively notable drifts in their own patterns. The present study also demonstrated that the current targets of DBS shared a common feature: their centrality values being relatively low in the normal brain while intensely drifting with PD. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the Strategic Priority Research Program of CAS (XDB02020000), National Program on Key Basic Research Project (973 Programs 2015CB755605, 2012CB825503, 2012CBA 01304), Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), Training Program of the Major Research Plan of the National Natural Science Foundation of China (91332120), National Natural Science Foundation of China (31271167, 81271495, 81471312, 81271248), The Yunnan Provincial Project to Attract One-hundred Exceptional Talents from Overseas, Selected Frontier Scientific Significant Breakthrough Project of CAS, International Cooperation Projection (2011C14026) of Zhejiang Province Department of Science and Technology. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9168]  |
| 专题 | 昆明动物研究所_神经系统编码 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 3.University of the Chinese Academy of Sciences, Beijing 100049, China 4.Sichuan University, Chengdu, Sichuan 610064, China 5.Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China |
| 推荐引用方式 GB/T 7714 | Lei X,Huang B[,Li H,et al. Drift in centrality of different brain regions in an anatomical neural network with Parkinson's disease: A view from complex network analysis[J]. NEUROSCIENCE,2015,299(X):107-124. |
| APA | Lei X,Huang B[,Li H,Jiang H,Hu X[*],&Zhang B[*].(2015).Drift in centrality of different brain regions in an anatomical neural network with Parkinson's disease: A view from complex network analysis.NEUROSCIENCE,299(X),107-124. |
| MLA | Lei X,et al."Drift in centrality of different brain regions in an anatomical neural network with Parkinson's disease: A view from complex network analysis".NEUROSCIENCE 299.X(2015):107-124. |
入库方式： OAI收割
来源：昆明动物研究所
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