Evidence for Conversion of Methanol to Formaldehyde in Nonhuman Primate Brain
文献类型：期刊论文
| 作者 | Zhai RW1,2,3; Zheng N1,2,3; Joshua Rizak1; Hu XT[*]1,4,5,6 |
| 刊名 | ANALYTICAL CELLULAR PATHOLOGY
 |
| 出版日期 | 2016 |
| 卷号 | 2016期号:X页码:e4598454 |
| 通讯作者 | xthu@mail.kiz.ac.cn |
| 英文摘要 | Many studies have reported that methanol toxicity to primates is mainly associated with its metabolites, formaldehyde (FA) and formic acid. While methanol metabolism and toxicology have been best studied in peripheral organs, little study has focused on the brain and no study has reported experimental evidence that demonstrates transformation of methanol into FA in the primate brain. In this study, three rhesus macaques were given a single intracerebroventricular injection of methanol to investigate whether a metabolic process of methanol to FA occurs in nonhuman primate brain. Levels of FA in cerebrospinal fluid (CSF) were then assessed at different time points. A significant increase of FA levels was found at the 18th hour following a methanol injection. Moreover, the FA level returned to a normal physiological level at the 30th hour after the injection. These findings provide direct evidence that methanol is oxidized to FA in nonhuman primate brain and that a portion of the FA generated is released out of the brain cells. This study suggests that FA is produced from methanol metabolic processes in the nonhuman primate brain and that FA may play a significant role in methanol neurotoxicology. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by National Program on Key Basic Research Projects (973 Programs 2015CB755605, 2012CB825503, and 2012CBA01304), the Strategic Priority Research Program of the Chinese Academy of Sciences, Grant no. XDB02020005, the Key Research Program of the Chinese Academy of Sciences, the National High Technol- ogy Research and Development Program of China (863 Program 2012AA0207010), Selected Frontier Scientific Sig- nificant Breakthrough Project of the CAS Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2), TrainingProgramoftheMajorResearchPlanoftheNational Natural Science Foundation of China (91332120), National NaturalScienceFoundationofChina(81471312,31271167,and 81271495),andtheYunnanProvincialProjecttoAttractOne- Hundred Exceptional Talents from Overseas. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9692]  |
| 专题 | 昆明动物研究所_神经系统编码 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 2.Kunming College of Life Science, University of the Chinese Academy of Sciences, Kunming 650204, China 3.University of the Chinese Academy of Sciences, Beijing 100049, China 4.CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China 5.Kunming Primate Research Center of the Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 6.Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan 650050, China |
| 推荐引用方式 GB/T 7714 | Zhai RW,Zheng N,Joshua Rizak,et al. Evidence for Conversion of Methanol to Formaldehyde in Nonhuman Primate Brain[J]. ANALYTICAL CELLULAR PATHOLOGY,2016,2016(X):e4598454. |
| APA | Zhai RW,Zheng N,Joshua Rizak,&Hu XT[*].(2016).Evidence for Conversion of Methanol to Formaldehyde in Nonhuman Primate Brain.ANALYTICAL CELLULAR PATHOLOGY,2016(X),e4598454. |
| MLA | Zhai RW,et al."Evidence for Conversion of Methanol to Formaldehyde in Nonhuman Primate Brain".ANALYTICAL CELLULAR PATHOLOGY 2016.X(2016):e4598454. |
入库方式： OAI收割
来源：昆明动物研究所
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