Effect of adrenalectomy and corticosterone replacement on prepulse inhibition and locomotor activity in mice
文献类型：期刊论文
| 作者 | van den Buuse M[*]1,2,4; Morris M2; Chavez C1; Martin S1; Wang JH1,3 |
| 刊名 | BRITISH JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2004 |
| 卷号 | 142期号:3页码:543-550 |
| 关键词 | corticosterone dopamine prepulse inhibition locoinotor hyperactivity mice |
| 通讯作者 | mvandenbuuse@mhri.edu.au |
| 合作状况 | 其它 |
| 英文摘要 | 1 Stress is a risk factor in psychiatric illnesses such as schizophrenia. The aim of the present study was to investigate the effect of different circulating levels of the adrenal steroid corticosterone (CORT) on locomotor hyperactivity and prepulse inhibition of acoustic startle, two behavioural animal models of aspects of schizophrenia. 2 Male C57BL/6J mice (n = 10 per group) were anaesthetised with isoflurane and sham-operated or adrenalectomised (ADX). ADX mice were implanted with 50 mg pellets consisting of 100% cholesterol, or 2, 10 or 50 mg of CORT mixed with cholesterol. CORT pellet implantation dose dependently increased plasma CORT levels 3 weeks after surgery. Starting 1 week after surgery, mice were tested for prepulse inhibition after injection of saline or 5 mg kg(-1) of haloperidol. 3 In intact mice and in mice implanted with 10 mg of CORT, haloperidol treatment significantly increased prepulse inhibition (average values from 38 - 42 to 52%). Similar results were observed when testing the mice for amphetamine-induced locomotor hyperactivity (5 mg kg(-1)). In contrast, there was no significant effect of haloperidol in mice implanted either with cholesterol or 2 or 50 mg of CORT. 4 These results in behavioural animal models of schizophrenia suggest an important role of the stress hormone CORT in modulating dopaminergic activity in this illness. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10614]  |
| 专题 | 昆明动物研究所_神经系统编码 |
| 作者单位 | 1.Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Victoria 3052, Australia 2.Department of Pharmacology, University of Melbourne, Melbourne, Australia 3.Section of Cognitive Brain Research, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650233, People’s Republic of China 4.Current address: Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Victoria 3052, Australia |
| 推荐引用方式 GB/T 7714 | van den Buuse M[*],Morris M,Chavez C,et al. Effect of adrenalectomy and corticosterone replacement on prepulse inhibition and locomotor activity in mice[J]. BRITISH JOURNAL OF PHARMACOLOGY,2004,142(3):543-550. |
| APA | van den Buuse M[*],Morris M,Chavez C,Martin S,&Wang JH.(2004).Effect of adrenalectomy and corticosterone replacement on prepulse inhibition and locomotor activity in mice.BRITISH JOURNAL OF PHARMACOLOGY,142(3),543-550. |
| MLA | van den Buuse M[*],et al."Effect of adrenalectomy and corticosterone replacement on prepulse inhibition and locomotor activity in mice".BRITISH JOURNAL OF PHARMACOLOGY 142.3(2004):543-550. |
入库方式： OAI收割
来源：昆明动物研究所
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