Do nuclear-encoded core subunits of mitochondrial complex I confer genetic susceptibility to schizophrenia in Han Chinese populations?
文献类型：期刊论文
| 作者 | Li X1,3; Zhang W1; Tang JS2; Tan LW2; Luo XJ1; Chen XG[*]2; Yao YG[*]1,4 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:X页码:e11076 |
| 通讯作者 | chenxghn@163.com ; yaoyg@mail.kiz.ac.cn |
| 英文摘要 | Schizophrenia is one of the most prevalent psychiatric disorders with complex genetic etiology. Accumulating evidence suggests that energy metabolism and oxidative stress play important roles in the pathophysiology of schizophrenia. Dysfunction of mitochondrial respiratory chain and altered expression of complex I subunits were frequently reported in schizophrenia. To investigate whether nuclear-encoded core subunit genes of mitochondrial complex I are associated with schizophrenia, we performed a genetic association study in Han Chinese. In total, 46 tag single nucleotide polymorphisms (SNPs) from 7 nuclear-encoded core genes of mitochondrial complex I were genotyped in 918 schizophrenia patients and 1042 healthy controls. We also analyzed these SNPs in a large sample mainly composed of Europeans through using the available GWAS datasets from the Psychiatric Genomics Consortium (PGC). No significant associations were detected between these SNPs and schizophrenia in Han Chinese and the PGC data set. However, we observed nominal significant associations of 2 SNPs in the NDUFS1 gene and 4 SNPs in the NDUFS2 gene with early onset schizophrenia (EOS), but none of these associations survived the Bonferroni correction. Taken together, our results suggested that common SNPs in the nuclear-encoded core subunit genes of mitochondrial complex I may not confer genetic susceptibility to schizophrenia. |
| 收录类别 | 其他 |
| 资助信息 | This study was supported by the Strategic Priority Research Program (B) of the Chinese Academy of Sciences (XDB02020000), the Ministry of Science and Technology of China (2011CB910900), National Natural Science Foundation of China (31171225) and the West Light Foundation of the Chinese Academy of Sciences. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9185]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_神经系统疾病 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Institute of Mental Health, the Second Xiangya Hospital, Central South University, Changsha 410011, China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650223, China 4.CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, Shanghai, 200031, China |
| 推荐引用方式 GB/T 7714 | Li X,Zhang W,Tang JS,et al. Do nuclear-encoded core subunits of mitochondrial complex I confer genetic susceptibility to schizophrenia in Han Chinese populations?[J]. SCIENTIFIC REPORTS,2015,5(X):e11076. |
| APA | Li X.,Zhang W.,Tang JS.,Tan LW.,Luo XJ.,...&Yao YG[*].(2015).Do nuclear-encoded core subunits of mitochondrial complex I confer genetic susceptibility to schizophrenia in Han Chinese populations?.SCIENTIFIC REPORTS,5(X),e11076. |
| MLA | Li X,et al."Do nuclear-encoded core subunits of mitochondrial complex I confer genetic susceptibility to schizophrenia in Han Chinese populations?".SCIENTIFIC REPORTS 5.X(2015):e11076. |
入库方式： OAI收割
来源：昆明动物研究所
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