Evaluation of European Schizophrenia GWAS Loci in Asian Populations via Comprehensive Meta-Analyses
文献类型：期刊论文
| 作者 | Xiao X1; Luo XJ1; Chang H1; Liu ZC2; Li M[*]1 |
| 刊名 | Mol Neurobiol
 |
| 出版日期 | 2016 |
| 卷号 | X期号:X页码:XX-XX |
| 关键词 | Asian European GWAS Meta-analyses Replication Schizophrenia |
| 通讯作者 | limingkiz@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 中文摘要 | Schizophrenia is a severe and highly heritable neuropsychiatric disorder. Recent genetic analyses including genome-wide association studies (GWAS) have implicated multiple genome-wide significant variants for schizophrenia among European populations. However, many of these risk variants were not largely validated in other populations of different ancestry such as Asians. To validate whether these European GWAS significant loci are associated with schizophrenia in Asian populations, we conducted a systematic literature search and meta-analyses on 19 single nucleotide polymorphisms (SNPs) in Asian populations by combining all available case-control and family-based samples, including up to 30,000 individuals. We employed classical fixed (or random) effects inverse variance weighted methods to calculate summary odds ratios (ORs) and 95 % confidence intervals (CIs). Among the 19 GWAS loci, we replicated the risk associations of nine markers (e.g., SNPs at VRK2, ITIH3/4, NDST3, NOTCH4) surpassing significance level (two-tailed P < 0.05), and three additional SNPs in MIR137 and ZNF804A also showed trend associations (one-tailed P < 0.05). These risk associations are in the same directions of allelic effects between Asian replication samples and initial European GWAS findings, and the successful replications of these GWAS loci in a different ethnic group provide stronger evidence for their clinical associations with schizophrenia. Further studies, focusing on the molecular mechanisms of these GWAS significant loci, will become increasingly important for understanding of the pathogenesis to schizophrenia. |
| 收录类别 | SCI |
| 资助信息 | The authors are deeply grateful for the authors of the included studies to share their results. This work was supported by CAS Pioneer Hundred Talents Program. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10074]  |
| 专题 | 昆明动物研究所_神经系统疾病 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_转化基因组 |
| 作者单位 | 1.Key Laboratory ofAnimal Models and Human Disease Mechanisms oftheChineseAcademyofSciencesandYunnanProvince,Kunming Institute of Zoology, Kunming, Yunnan, China 2.Key Laboratory of Special Biological Resource Development and Utilization of Universities in Yunnan Province, Department of Biological Science and Technology, Kunming University, Kunming, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Xiao X,Luo XJ,Chang H,et al. Evaluation of European Schizophrenia GWAS Loci in Asian Populations via Comprehensive Meta-Analyses[J]. Mol Neurobiol,2016,X(X):XX-XX. |
| APA | Xiao X,Luo XJ,Chang H,Liu ZC,&Li M[*].(2016).Evaluation of European Schizophrenia GWAS Loci in Asian Populations via Comprehensive Meta-Analyses.Mol Neurobiol,X(X),XX-XX. |
| MLA | Xiao X,et al."Evaluation of European Schizophrenia GWAS Loci in Asian Populations via Comprehensive Meta-Analyses".Mol Neurobiol X.X(2016):XX-XX. |
入库方式： OAI收割
来源：昆明动物研究所
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