Identification of SLC25A37 as a major depressive disorder risk gene
文献类型：期刊论文
| 作者 | Huo YX1; Huang L2; Zhang C[*]3; Luo XJ[*]1; Zhang DF1; Yao YG1; Fang YR3 |
| 刊名 | Journal of Psychiatric Research
 |
| 出版日期 | 2016 |
| 卷号 | 83期号:X页码:168-175 |
| 关键词 | Major depressive disorder (MDD) Expression Genetic association Integrative analysis Major depressive disorder (MDD) SLC25A37 |
| 通讯作者 | zhangchen645@gmail.com ; luoxiongjian@mail.kiz. ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Major depressive disorder (MDD) is one of the most prevalent and disabling mental disorders, but the genetic etiology remains largely unknown. We performed a meta-analysis (14,543 MDD cases and 14,856 controls) through combining the GWAS data from the Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium and the CONVERGE consortium and identified seven SNPs (four of them located in the downstream of SCL25A37) that showed suggestive associations (P < 5.0 × 10-7) with MDD. Systematic integration (Sherlock integrative analysis) of brain eQTL and GWAS meta-analysis identified SCL25A37 as a novel MDD risk gene (P = 2.22 × 10-6). A cis SNP (rs6983724, ∼28 kb downstream of SCL25A37) showed significant association with SCL25A37 expression (P = 1.19 × 10-9) and suggestive association with MDD (P = 1.65 × 10-7). We validated the significant association between rs6983724 and SCL25A37 expression in independent expression datasets. Finally, we found that SCL25A37 is significantly down-regulated in hippocampus and blood of MDD patients (P = 3.49 × 10-3 and P = 2.66 × 10-13, respectively). Our findings implicate that the SCL25A37 is a MDD susceptibility gene whose expression may influence MDD risk. The consistent down-regulation of SCL25A37 in MDD patients in three independent samples suggest that SCL25A37 may be used as a potential biomarker for MDD diagnosis. Further functional characterization of SCL25A37 may provide a potential target for future therapeutics and diagnostics. |
| 收录类别 | SCI |
| 资助信息 | X.J.L was supported by the 100 Talents Program (BaiRenJiHua) of the Kunming Institute of Zoology, Chinese Academy of Sciences, and Project of Thousand Youth Talents of China. Y.G.Y was sup- ported by the Strategic Priority Research Program (B) of the Chinese Academy of Sciences (XDB02020003). C.Z. was supported by the National Natural Science Foundation of China (81471358) and the Shanghai Municipal Education CommissiondGaofeng Clinical Medicine Grant Support (20152530). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10485]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_神经系统疾病 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi 341000, Chin 3.Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China |
| 推荐引用方式 GB/T 7714 | Huo YX,Huang L,Zhang C[*],et al. Identification of SLC25A37 as a major depressive disorder risk gene[J]. Journal of Psychiatric Research,2016,83(X):168-175. |
| APA | Huo YX.,Huang L.,Zhang C[*].,Luo XJ[*].,Zhang DF.,...&Fang YR.(2016).Identification of SLC25A37 as a major depressive disorder risk gene.Journal of Psychiatric Research,83(X),168-175. |
| MLA | Huo YX,et al."Identification of SLC25A37 as a major depressive disorder risk gene".Journal of Psychiatric Research 83.X(2016):168-175. |
入库方式： OAI收割
来源：昆明动物研究所
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