Processing of visually evoked innate fear by a non-canonical thalamic pathway
文献类型：期刊论文
| 作者 | Wei PF1; Liu N1; He XB2; Wu BF1; Zhou Z1; Liu YH1; Li J1; Zhang YP[1]*1; Zhang ZJ2,3; Zhou XY1 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2015-07 |
| 卷号 | 6期号:X页码:e6756 |
| 通讯作者 | lp.wang@siat.ac.cn |
| 英文摘要 | The ability of animals to respond to life-threatening stimuli is essential for survival. Although vision provides one of the major sensory inputs for detecting threats across animal species, the circuitry underlying defensive responses to visual stimuli remains poorly defined. Here, we investigate the circuitry underlying innate defensive behaviours elicited by predator-like visual stimuli in mice. Our results demonstrate that neurons in the superior colliculus (SC) are essential for a variety of acute and persistent defensive responses to overhead looming stimuli. Optogenetic mapping revealed that SC projections to the lateral posterior nucleus (LP) of the thalamus, a non-canonical polymodal sensory relay, are sufficient to mimic visually evoked fear responses. In vivo electrophysiology experiments identified a di-synaptic circuit from SC through LP to the lateral amygdale (Amg), and lesions of the Amg blocked the full range of visually evoked defensive responses. Our results reveal a novel collicular-thalamic-Amg circuit important for innate defensive responses to visual threats. |
| 收录类别 | SCI |
| 资助信息 | This project was partly supported by: the National Natural Science Foundation of China under grant numbers NSFC 81425010 (L.W.), 91132306/ H09 (L.W.), 91132307/H09 (F.X.), 31171061/C090208 (F.X.) and Y5Z1161001 (F.X.); Strategic Priority Research Program (B) under grant numbers XDB02050300 (L.W.) and XDB02050500 (F.X.); the Instrument Developing Project under grant number 2010019 (L.W.); Key Laboratory for Health Informatics (L.W.) of the CAS, the National Key Technology Research and Development Program of the Ministry of Science and Tech- nology of China under grant number 2012BAI01B08 (L.W.), the National Basic Research Program (973 Program) of China under grant numbers 2010CB529605 (L.W.), 2012CB825500 (L.C.) and 2015CB755600 (F.X.); Guangdong Innovative and Entrepreneurial Research Team Fund for Low-cost Healthcare Technologies (L.W.) and Program (No. 2013S046) (P.W.), Shenzhen Peacock Plan (P.W.) and the Project of ‘Shenzhen Engineering Laboratory for Brain Activity Mapping Technologies’ (P.W.). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10788]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 昆明动物研究所_神经系统编码 |
| 作者单位 | 1.Shenzhen Key Lab of Neuropsychiatric Modulation and Collaborative Innovation Center for Brain Science, CAS Center for Excellence in Brain Science, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China 2.Wuhan Institute of Physics and Mathematics, CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, Wuhan 430071, China 3.College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430071, China 4.College of Life Science, Wuhan University, Wuhan 430071, China 5.Institute of Zoology, CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, Kunming 650223, Chin 6.State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, Beijing 100101, China 7.CAS Key Laboratory of Brain Function and Disease, and School of Life Sciences, CAS Center for Excellence in Brain Science, The University of Science and Technology of China, Hefei 230026, China |
| 推荐引用方式 GB/T 7714 | Wei PF,Liu N,He XB,et al. Processing of visually evoked innate fear by a non-canonical thalamic pathway[J]. NATURE COMMUNICATIONS,2015,6(X):e6756. |
| APA | Wei PF.,Liu N.,He XB.,Wu BF.,Zhou Z.,...&Tang YQ.(2015).Processing of visually evoked innate fear by a non-canonical thalamic pathway.NATURE COMMUNICATIONS,6(X),e6756. |
| MLA | Wei PF,et al."Processing of visually evoked innate fear by a non-canonical thalamic pathway".NATURE COMMUNICATIONS 6.X(2015):e6756. |
入库方式： OAI收割
来源：昆明动物研究所
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